Inflammation is a part of an elaborate human defence system. This process needs a functioning immune system to allow the defence against dangers such as mechanical, chemical and biological signals or at least to contain and therefore prevent organ damage. The human body responds rapidly to dangers by an inflammatory response, which is also rapidly resolved after the dangers have been removed allowing for tissue repair to begin. How resolution of inflammation functions is still inadequately researched and will thus be researched by the CRC1181.
The Collaborative Research Centre (CRC) 1181 titled Checkpoints for Resolution of Inflammation is funded by the German Research Council (DFG) since July, 1st, 2015 and was established to investigate the molecular mechanisms involved in the resolution of inflammation. Our main focus is on why resolution of inflammation fails in chronic inflammatory diseases such as arthritis, Crohn’s disease and asthma which are characterized by chronic inflammation of the inner surfaces of the body, usually having serious health implications for its patients.