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J Immunol. 2017 Feb 13. pii: 1600802. doi: 10.4049/jimmunol.1600802. [Epub ahead of print]

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes.

Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.
Gastroenterology. 2017 Jan;152(1):176-192.e5. doi: 10.1053/j.gastro.2016.09.005. Epub 2016 Sep 14.

Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.

Popp V, Gerlach K, Mott S, Turowska A, Garn H, Atreya R, Lehr HA, Ho IC, Renz H, Weigmann B, Neurath MF.
Autoimmunity. 2017 Jan 13:1-7. doi: 10.1080/08916934.2016.1261837. [Epub ahead of print]

Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites.

Sarter K, Kulagin M, Schett G, Harris NL, Zaiss MM.
Front Immunol. 2016 Dec 9;7:583. doi: 10.3389/fimmu.2016.00583. eCollection 2016.

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs.

Maueröder C, Mahajan A, Paulus S, Gößwein S, Hahn J, Kienhöfer D, Biermann MH, Tripal P, Friedrich RP, Munoz LE, Neurath MF, Becker C, Schett GA, Herrmann M, Leppkes M.
Front Immunol. 2016 Dec 1;7:557. eCollection 2016.

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation.

Biermann MH, Podolska MJ, Knopf J, Reinwald C, Weidner D, Maueröder C, Hahn J, Kienhöfer D, Barras A, Boukherroub R, Szunerits S, Bilyy R, Hoffmann M, Zhao Y, Schett G, Herrmann M, Munoz LE.
Nat Med. 2016 Dec 6;22(12):1384-1386. doi: 10.1038/nm.4217.

Reply to “Neutrophils are not required for resolution of acute gouty arthritis in mice”.

Reinwald C, Schauer C, Csepregi JZ, Kienhöfer D, Weidner D, Malissen M, Mocsai A, Schett G, Herrmann M, Hoffmann M.
Nat Immunol. 2016 Nov 7. doi: 10.1038/ni.3579. [Epub ahead of print]

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.
J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17.

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.

Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S.
Front Immunol. 2016 Oct 10;7:424. eCollection 2016.

Neutrophil Extracellular Traps Form a Barrier between Necrotic and Viable Areas in Acute Abdominal Inflammation.

Bilyy R, Fedorov V, Vovk V, Leppkes M, Dumych T, Chopyak V, Schett G, Herrmann M.
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5856-E5865. Epub 2016 Sep 19.

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation.

Muñoz LE, Bilyy R, Biermann MH, Kienhöfer D, Maueröder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y, Herrmann M.

Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.
Front Immunol. 2016 Aug 12;7:302. doi: 10.3389/fimmu.2016.00302. eCollection 2016.

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.

Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M.
J Exp Med. 2016 Aug 8. pii: jem.20160316. [Epub ahead of print]

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.

von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L.
Gastroenterology. 2016 Aug;151(2):238-40. doi: 10.1053/j.gastro.2016.05.047. Epub 2016 Jun 3.

Multispectral Optoacoustic Tomography in Crohn’s Disease: Noninvasive Imaging of Disease Activity.

Waldner MJ, Knieling F, Egger C, Morscher S, Claussen J, Vetter M, Kielisch C, Fischer S, Pfeifer L, Hagel A, Goertz RS, Wildner D, Atreya R, Strobel D, Neurath MF.
J Mol Med (Berl). 2015 Jul;93(7):727-34. doi: 10.1007/s00109-015-1295-x. Epub 2015 May 24.

How neutrophil extracellular traps orchestrate the local immune response in gout.

Maueröder C, Kienhöfer D, Hahn J, Schauer C, Manger B, Schett G, Herrmann M, Hoffmann MH.
Lupus. 2016 Jul;25(8):943-54. doi: 10.1177/0961203316640919.

Reactive oxygen homeostasis – the balance for preventing autoimmunity.

Kienhöfer D, Boeltz S, Hoffmann MH.
Lupus. 2016 Jul;25(8):934-42. doi: 10.1177/0961203316640368.

Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and inflammation.

Biermann MH, Griffante G, Podolska MJ, Boeltz S, Stürmer J, Muñoz LE, Bilyy R, Herrmann M.
Biochim Biophys Acta. 2016 Jul 30. pii: S1388-1981(16)30219-0. doi: 10.1016/j.bbalip.2016.07.014. [Epub ahead of print]

The double-edged role of 12/15-lipoxygenase during inflammation and immunity.

Ackermann JA, Hofheinz K, Zaiss MM, Krönke G.
J Exp Med. 2016 Jul 25;213(8):1627-44. doi: 10.1084/jem.20160189. Epub 2016 Jul 4.

Siglec-H protects from virus-triggered severe systemic autoimmunity.

Schmitt H, Sell S, Koch J, Seefried M, Sonnewald S, Daniel C, Winkler TH, Nitschke L.
Nat Commun. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596.

Th2 and eosinophil responses suppress inflammatory arthritis.

Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G, Bozec A.
Cell Rep. 2016 May 3;15(5):1062-75. doi: 10.1016/j.celrep.2016.04.001. Epub 2016 Apr 21.

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Körner H, Bogdan C.

Oncotarget. 2016 Mar 30. doi: 10.18632/oncotarget.8474. [Epub ahead of print]

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.

Chen GL, Luo Y, Eriksson D, Meng X, Qian C, Bäuerle T, Chen XX, Schett G, Bozec A.

Mehr…

Cell Death Differ. 2016 Jun;23(6):1016-25. doi: 10.1038/cdd.2016.4. Epub 2016 Mar 4.

A blast without power – cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses.

Maueröder C, Chaurio RA, Dumych T, Podolska M, Lootsik MD, Culemann S, Friedrich RP, Bilyy R, Alexiou C, Schett G, Berens C, Herrmann M, Munoz LE.

J Immunol. 2016 May 1;196(9):3581-94. doi: 10.4049/jimmunol.1502163. Epub 2016 Mar 16.

CD83 Modulates B Cell Activation and Germinal Center Responses.

Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L.

Nat Commun. 2016 Mar 11;7:10973. doi: 10.1038/ncomms10973.

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitits.

Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C.

Mehr…

Ann Rheum Dis. 2016 Feb 25. pii: annrheumdis-2015-208821. doi: 10.1136/annrheumdis-2015-208821. [Epub ahead of print]

Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis.

Faustini F, Simon D, Oliveira I, Kleyer A, Haschka J, Englbrecht M, Cavalcante AR, Kraus S, Tabosa TP, Figueiredo C, Hueber AJ2, Kocijan R3, Cavallaro A5, Schett G2, Sticherling M6, Rech J2.

Mehr…

Cell Death Differ. 2016 Feb 26. doi: 10.1038/cdd.2016.11. [Epub ahead of print] Review.

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.

Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M.

Mehr…

Cell Rep. 2016 Feb 9;14(5):1062-73. doi: 10.1016/j.celrep.2016.01.010. Epub 2016 Jan 28.

Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis.

Martini E, Wittkopf N, Günther C, Leppkes M, Okada H, Watson AJ, Podstawa E, Backert I, Amann K, Neurath MF, Becker C.

Mehr…

J Crohns Colitis. 2016 Jan 27. pii: jjw012. [Epub ahead of print]

High-resolution quantitative computed tomography demonstrates structural defects in cortical and trabecular bone in IBD patients.

Haschka J, Hirschmann S, Kleyer A, Englbrecht M, Faustini F, Simon D, Figueiredo CP, Schuster L, Muschitz C, Kocijan R, Resch H, Atreya R, Rech J, Neurath MF, Schett G.

Mehr…

Front Microbiol. 2016 Jan 22;6:1520. doi: 10.3389/fmicb.2015.01520. eCollection 2015.

Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response.

Fromm PD, Kling JC, Remke A, Bogdan C, Körner H.

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Gut. 2016. 2016 Jan 18. pii: gutjnl-2015-310374. doi: 10.1136/gutjnl-2015-310374. [Epub ahead of print]

IL-36R signaling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C.

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Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17.

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A.

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Cell Rep. 2015 Oct 20;13(3):610-20. doi: 10.1016/j.celrep.2015.09.013. Epub 2015 Oct 8.

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Schwab I, Lux A, Nimmerjahn F.

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Int J Mol Sci. 2015 Aug 12;16(8):18825-35. doi: 10.3390/ijms160818825.

Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment.

Fürnrohr BG, Rhodes B, Munoz LE, Weiß K, Vyse TJ, Schett G.

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