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2019

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G493-G507. doi: 10.1152/ajpgi.00297.2018. Epub 2019 Aug 14.

Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate.

Kaden-Volynets V, Günther C, Zimmermann J, Beisner J, Becker C, Bischoff SC.
FEBS J. 2019 Oct;286(20):3980-3997. doi: 10.1111/febs.14962. Epub 2019 Jun 27.

Specific high affinity interaction of Helicobacter pylori CagL with integrin αV β6 promotes type IV secretion of CagA into human cells.

Buß M, Tegtmeyer N, Schnieder J, Dong X, Li J, Springer TA, Backert S, Niemann HH.
JCI Insight. 2019 Oct 17;4(20). pii: 126246. doi: 10.1172/jci.insight.126246.

CD83 orchestrates immunity toward self and non-self in dendritic cells.

Wild AB, Krzyzak L, Peckert K, Stich L, Kuhnt C, Butterhof A, Seitz C, Mattner J, Grüner N, Gänsbauer M, Purtak M, Soulat D, Winkler TH, Nitschke L, Zinser E, Steinkasserer A.
Mol Metab. 2019 Oct;28:73-82. doi: 10.1016/j.molmet.2019.08.002. Epub 2019 Aug 5.

Short-term cold exposure supports human Treg induction in vivo.

Becker M, Serr I, Salb VK, Ott VB, Mengel L, Blüher M, Weigmann B, Hauner H, Tschöp MH, Daniel C.
Nutrients. 2019, 11(10), 2392; https://doi.org/10.3390/nu11102392

The Role of Dietary Fiber in Rheumatoid Arthritis Patients: A Feasibility Study

Häger J, Bang H, Hagen M, Frech M, Träger P, Sokolova MV, Steffen U, Tascilar K, Sarter K, Schett G, Rech J, Zaiss MM.

Semin Immunopathol (2019). Review. https://doi.org/10.1007/s00281-019-00756-1

Resolution of Crohn’s disease

Schmitt H, Neufert C, Neurath MF, Atreya R.

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Eur J Immunol. 2019 Sep;(1)42-42. Meeting abstract.

Antigen targeting of Fc receptors induces strong and functional relevant T cell responses in vivo independent of ITAM signaling but dependent on dendritic cell subsets

Lehmann CHK, Baranska A, Heidkamp GF, Amon L, Seeling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D.
 
J Mol Med (Berl). 2019 Oct;97(10):1377-1383. doi: 10.1007/s00109-019-01826-5. Epub 2019 Aug 8.

The dichotomous function of interleukin-9 in cancer diseases.

Gerlach K, Weigmann B.
 
Immunity. 2019 Sep 17;51(3):443-450.e4. doi: 10.1016/j.immuni.2019.07.002. Epub 2019 Aug 15.

Neutrophil Extracellular Traps Initiate Gallstone Formation.

Muñoz LE, Boeltz S, Bilyy R, Schauer C, Mahajan A, Widulin N, Grüneboom A, Herrmann I, Boada E, Rauh M, Krenn V, Biermann MHC, Podolska MJ, Hahn J, Knopf J, Maueröder C, Paryzhak S, Dumych T, Zhao Y, Neurath MF, Hoffmann MH, Fuchs TA, Leppkes M, Schett G, Herrmann M.
Ann Rheum Dis. 2019 Sep;78(9):1269-1273. doi: 10.1136/annrheumdis-2019-215066. Epub 2019 Jun 8.

Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc.

Liang R, Kagwiria R, Zehender A, Dees C, Bergmann C, Ramming A, Krasowska D, Michalska-Jakubus M, Kreuter A, Kraner ME, Schett G, Distler JHW.
Front. Immunol. 2019 Sept 11. doi.org/10.3389/fimmu.2019.02176

Aggregated NETs Sequester and Detoxify Extracellular Histones

Knopf J, Leppkes M, Schett G, Herrmann M, Muñoz L.
J Leukoc Biol. 2019 Sep 2. doi: 10.1002/JLB.3AB0918-370R. [Epub ahead of print]

Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs.

Podolska MJ, Mahajan A, Hahn J, Knopf J, Maueröder C, Petru L, Ullmann M, Schett G, Leppkes M, Herrmann M, Muñoz LE, Schauer C.
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Nature. 2019 Aug;572(7771):670-675. doi: 10.1038/s41586-019-1471-1. Epub 2019 Aug 7.

Locally renewing resident synovial macrophages provide a protective barrier for the joint.

Culemann S, Grüneboom A, Nicolás-Ávila JÁ, Weidner D, Lämmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Bäuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Krönke G.
Nat Rev Nephrol. 2019 Sep;15(9):559-575. doi: 10.1038/s41581-019-0163-2. Epub 2019 Jun 18.

Extracellular DNA traps in inflammation, injury and healing.

Daniel C, Leppkes M, Muñoz LE, Schley G, Schett G, Herrmann M.
Trends Microbiol. 2019 Sep;27(9):731-738. doi: 10.1016/j.tim.2019.04.010. Epub 2019 May 23.

Classification of Helicobacter pylori Virulence Factors: Is CagA a Toxin or Not?

Knorr J, Ricci V, Hatakeyama M, Backert S.
Nature. 2019 Aug 7. doi: 10.1038/s41586-019-1471-1. [Epub ahead of print]

Locally renewing resident synovial macrophages provide a protective barrier for the joint.

Culemann S, Grüneboom A, Nicolás-Ávila JÁ, Weidner D, Lämmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Bäuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Krönke G.
J Clin Invest. 2019 Jul 15;129(8):3018-3028. doi: 10.1172/JCI128521. eCollection 2019 Jul 15.

The gut-bone axis: how bacterial metabolites bridge the distance.

Zaiss MM, Jones RM, Schett G, Pacifici R.
Arthritis Res Ther. 2019 Jul 26;21(1):178. doi: 10.1186/s13075-019-1957-0.

Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation-data from the prospective IVEPSA study.

Kampylafka E, Simon D, d’Oliveira I, Linz C, Lerchen V, Englbrecht M, Rech J, Kleyer A, Sticherling M, Schett G, Hueber AJ.
Nat Immunol. 2019 Aug;20(8):970-979. doi: 10.1038/s41590-019-0415-0. Epub 2019 Jun 24.

Targeting immune cell circuits and trafficking in inflammatory bowel disease.

Neurath MF.
 
Kidney Int. 2019 Aug;96(2):378-396. doi: 10.1016/j.kint.2019.02.016. Epub 2019 Mar 5.

Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.

Schley G, Klanke B, Kalucka J, Schatz V, Daniel C, Mayer M, Goppelt-Struebe M, Herrmann M, Thorsteinsdottir M, Palsson R, Beneke A, Katschinski DM, Burzlaff N, Eckardt KU, Weidemann A, Jantsch J, Willam C.
Cancers 2019, 11(6), 799; doi.org/10.3390/cancers11060799

The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1 alpha in Gastric Cells

Valenzuela-Valderrama M, Cerda-Opazo P, Backert S, Gonzalez MF, Carrasco-Veliz N, Jorquera-Cordero C, Wehinger S, Canales J, Bravo D, Quest AF.

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J Leukoc Biol. 2019 Jun;105(6):1087-1098. doi: 10.1002/JLB.HI0718-249RR. Epub 2019 Apr 12.

Frontline Science: Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface.

Mahajan A, Grüneboom A, Petru L, Podolska MJ, Kling L, Maueröder C, Dahms F, Christiansen S, Günter L, Krenn V, Jünemann A, Bock F, Schauer C, Schett G, Hohberger B, Herrmann M, Muñoz LE.
J Bone Miner Res. 2019 Jul;34(7):1352-1365. doi: 10.1002/jbmr.3705. Epub 2019 Mar 19.

Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss.

Grötsch B, Lux A, Rombouts Y, Hoffmann AC, Andreev D, Nimmerjahn F, Xiang W, Scherer HU, Schett G, Bozec A.
 
Arthritis Res Ther. 2019 Jul 3;21(1):162. doi: 10.1186/s13075-019-1938-3.

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients.

Simon D, Kleyer A, Bayat S, Tascilar K, Kampylafka E, Meinderink T, Schuster L, Petrov R, Liphardt AM, Rech J, Schett G, Hueber AJ.
Frontier Immunol. 2019 Jul 3;10. doi:10.3389/fimmu.2019.01483

How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis

Steffen U, Schett G, Bozec A.

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Therap Adv  Gastroenterol. 2019 Jun 14;12:1756284819856865. doi: 10.1177/1756284819856865. eCollection 2019. Review. PubMed PMID: 31236140; PubMed Central PMCID: PMC6572879.

Targeting mucosal healing in Crohn’s disease: what the clinician needs to know.

Klenske E, Bojarski C, Waldner M, Rath T, Neurath MF, Atreya R.

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JCI Insight. 2019 Jun 4;5. pii: 128664. doi: 10.1172/jci.insight.128664.

Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cellkilling capability.

Ribechini E, Eckert I, Beilhack A, Du Plessis N, Walzl G, Schleicher U, Ritter U, Lutz MB.
Frontier Immunol. 2019 Jun 25;10. doi:10.3389/fimmu.2019.01442

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Zinser E, Naumann R, Wild AB, Michalski J, Deinzer A, Stich L, Kuhnt C, Steinkasserer A, Knippertz I.

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Frontier Immunol. 2019 Jun 25;10. Review. doi:10.3389/fimmu.2019.01449

The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells

Gerth E, Mattner J.

Nature. 2019 Jun;570(7760):246-251. doi: 10.1038/s41586-019-1263-7. Epub 2019 May 29.

Distinct fibroblast subsets drive inflammation and damage in arthritis.

Croft AP, Campos J, Jansen K, Turner JD, Marshall J, Attar M, Savary L, Wehmeyer C, Naylor AJ, Kemble S, Begum J, Dürholz K, Perlman H, Barone F, McGettrick HM, Fearon DT, Wei K, Raychaudhuri S, Korsunsky I, Brenner MB, Coles M, Sansom SN, Filer A, Buckley CD.
Cell Microbiol. 2019 Jul;21(7):e13022. doi: 10.1111/cmi.13022. Epub 2019 Mar 19.

How many protein molecules are secreted by single Helicobacter pylori cells: Quantification of serine protease HtrA.

Neddermann M, Backert S.
Frontiers Immunol. June 2019. Review. doi: 10.3389/fimmu.2019.01449

The role of adaptor proteins in the biology of natural killer T (NKT) cells

Gerth E, Mattner J.

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Rheumatology (Oxford). 2019 Feb 7. doi: 10.1093/rheumatology/key448. [Epub ahead of print]

Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants.

Löhr S, Ekici AB, Uebe S, Büttner C, Köhm M, Behrens F, Böhm B, Sticherling M, Schett G, Simon D, Mössner R, Nimeh A, Oji V, Assmann G, Rech J, Holmdahl R, Burkhardt H, Reis A, Hüffmeier U.
Gut. 2019 May;68(5):814-828. doi: 10.1136/gutjnl-2017-315671. Epub 2018 May 30.

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease.

Schmitt H, Billmeier U, Dieterich W, Rath T, Sonnewald S, Reid S, Hirschmann S, Hildner K, Waldner MJ, Mudter J, Hartmann A, Grützmann R, Neufert C, Münster T, Neurath MF, Atreya R.
Sci Immunol. 2019 May 24;4(35). pii: eaau3814. doi: 10.1126/sciimmunol.aau3814.

RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection.

Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Krönke G, Voehringer D.
PLoS Genet. May 2019. 15(5): e1008178. https://doi.org/10.1371/journal. pgen.1008178

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

Mattner J, Mohammed JP, Fusakio ME, Giessler C, Hackstein C-P, Opoka R, et al.
Sci Rep. 2019 May 8;9(1):7089. doi: 10.1038/s41598-019-43607-7.

Microvesicles from cerebrospinal fluid of patients with Alzheimer’s disease display reduced concentrations of tau and APP Protein.

Spitzer P, Mulzer LM, Oberstein TJ, Munoz LE, Lewczuk P, Kornhuber J, Herrmann M, Maler JM.

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J Allergy Clin Immunol. 2019 May;143(5):1849-1864.e4. doi: 10.1016/j.jaci.2018.08.052. Epub 2018 Oct 17.

Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming Efficiency

Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck, A.

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PEERJ. 2019 May. 7. DOI: 10.7717/peerj.6634

Molecular evolution of the VacA p55 binding domain of Helicobacter pylori in mestizos from a high gastric cancer region of Colombia

Gutierrez-Escobar AJ, Bravo MM, Acevedo O, Backert S.

Nat Methods. 2019 Apr;16(4):278-280. doi: 10.1038/s41592-019-0359-1.

3Dscript: animating 3D/4D microscopy data using a natural-language-based syntax.

Schmid B, Tripal P, Fraaß T, Kersten C, Ruder B, Grüneboom A, Huisken J, Palmisano R.
J Clin Invest. 2019 Apr 16;130:2669-2684. doi: 10.1172/JCI96832.

Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.

Hannemann N, Cao S, Eriksson D, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S, Ekici A, Cañete JD, Chen X, Bäuerle T, Vera J, Bogdan C, Schett G, Bozec A.
 

Front Pharmacol. 2019 Apr 24;10:314.  doi: 10.3389/fphar.2019.00314. eCollection 2019. Review. PubMed PMID: 31068803; PubMed Central PMCID: PMC6491809.

Oligonucleotides-A  Novel Promising Therapeutic Option for IBD.

Scarozza P, Schmitt H, Monteleone G, Neurath MF, Atreya R.

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Front Immunol. 2019 Apr 2;10:633. doi: 10.3389/fimmu.2019.00633. eCollection 2019.

Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner.

Royzman D, Andreev D, Stich L, Rauh M, Bäuerle T, Ellmann S, Boon L, Kindermann M, Peckert K, Bozec A, Schett G, Steinkasserer A, Zinser E.
J Vis Exp. 2019 Apr 16;(146). doi: 10.3791/59043.

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy.

Schulz-Kuhnt A, Zundler S, Grüneboom A, Neufert C, Wirtz S, Neurath MF, Atreya I.

Int J Mol Sci. 2019 Apr 16;20(8). pii: E1887. doi: 10.3390/ijms20081887. Review.

Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases.

Ruder B, Atreya R, Becker C.

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Nat Immunol. 2019 Mar;20(3):288-300. doi: 10.1038/s41590-018-0298-5. Epub 2019 Jan 28.

Hobit– and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal Inflammation.

Zundler S, Becker E, Spocinska M, Slawik M, Parga-Vidal L, Stark R, Wiendl M, Atreya R, Rath T, Leppkes M, Hildner K, López-Posadas R, Lukassen S, Ekici AB, Neufert C, Atreya I, van Gisbergen KPJM, Neurath MF.
 
Stem Cell Res. 2019 Mar;35:101383. doi: 10.1016/j.scr.2019.101383. Epub 2019 Feb 7.

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.

Bardenbacher M, Ruder B, Britzen-Laurent N, Schmid B, Waldner M, Naschberger E, Scharl M, Müller W, Günther C2, Becker C, Stürzl M, Tripal P.
J Immunol. 2019 Mar 1;202(5):1453-1464. doi: 10.4049/jimmunol.1801249. Epub 2019 Jan 21.

Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1.

Paduch K, Debus A, Rai B, Schleicher U, Bogdan C.
Curr Opin Microbiol. 2019 Feb;47:59-65. doi: 10.1016/j.mib.2018.11.010. Epub 2019 Jan 11.

Modulation of host cell metabolism by T4SS-encoding intracellular pathogens.

Hayek I, Berens C, Lührmann A.
Gastroenterology. 2019 Feb;156(3):692-707.e7. doi: 10.1053/j.gastro.2018.10.023. Epub 2018 Oct 10.

Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.

Tang Y, Reissig S, Glasmacher E, Regen T, Wanke F, Nikolaev A, Gerlach K, Popp V, Karram K, Fantini MC, Schattenberg JM, Galle PR, Neurath MF, Weigmann B, Kurschus FC, Hövelmeyer N, Waisman A.
Nature. 2019 Feb;566(7744):344-349. doi: 10.1038/s41586-019-0896-x. Epub 2019 Jan 30.

PU.1 controls fibroblast polarization and tissue fibrosis.

Wohlfahrt T, Rauber S, Uebe S, Luber M, Soare A, Ekici A, Weber S, Matei AE1, Chen CW, Maier C, Karouzakis E, Kiener HP, Pachera E, Dees C, Beyer C, Daniel C, Gelse K, Kremer AE, Naschberger E, Stürzl M, Butter F, Sticherling M, Finotto S, Kreuter A, Kaplan MH, Jüngel A, Gay S, Nutt SL Boykin DW, Poon GMK, Distler O, Schett G, Distler JHW, Ramming A.
 
Front Immunol. 2019 Feb 8;10:165. doi: 10.3389/fimmu.2019.00165. eCollection 2019.

MyD88 Is Required for Efficient Control of Coxiella burnetii Infection and Dissemination.

Kohl L, Hayek I, Daniel C, Schulze-Lührmann J, Bodendorfer B, Lührmann A, Lang R.
FASEB J. 2019 Jan;33(1):1401-1414. doi: 10.1096/fj.201800752R. Epub 2018 Aug 21.

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from anti-proteases.

Hahn J, Schauer C, Czegley C, Kling L, Petru L, Schmid B, Weidner D, Reinwald C, Biermann MHC, Blunder S, Ernst J, Lesner A, Bäuerle T, Palmisano R, Christiansen S, Herrmann M, Bozec A, Gruber R, Schett G, Hoffmann MH

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Cell Death Differ. 2019 Jan 8. doi: 10.1038/s41418-018-0261-x. [Epub ahead of print]

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.

Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M.

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J Allergy Clin Immunol. 2019 Jan;143(1):201-212.e4. doi: 10.1016/j.jaci.2018.02.041. Epub 2018 Mar 21.

Wheat amylase-trypsin inhibitors exacerbate intestinal and airway allergic immune responses in humanized mice

Bellinghausen I, Weigmann B, Zevallos V, Maxeiner J  Reißig S, Waisman A, Schuppan D, Saloga J.

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Nature Reviews Rheumatology Volume 15, pages9–17 (2019) doi: 10.1038/s41584-018-0109-2.

Anti-inflammatory and immune-regulatory cytokines in rheumatoid Arthritis

Chen Z, Bozec A, Ramming A, Schett G.

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2018

Am J Gastroenterol. 2018 Dec;113(12):1908-1910. doi: 10.1038/s41395-018-0394-z. Epub 2018 Oct 23.

Successful Long-term Treatment of Diversion Colitis with Topical Coconut Oil Application.

Zundler S, Dietz L, Matzel KE, Geppert CI, Becker E, Rath T, Neurath MF, Atreya R.

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Nat Commun. 2018 Nov 5;9(1):4613. doi: 10.1038/s41467-018-06933-4.

Mechanical strain determines the site-specific localization of inflammation and tissue damage in Arthritis.

Cambré I, Gaublomme D, Burssens A, Jacques P, Schryvers N, De Muynck A, Meuris L, Lambrecht S,, Carter S, de Bleser P, Saeys Y, Van Hoorebeke L, Kollias G, Mack M, Simoens P, Lories R, Callewaert N, Schett G, Elewaut D.

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J Vis Exp. 2018 Nov 20;(141). doi: 10.3791/58486.

Label-Free Imaging of Single Proteins Secreted from Living Cells via iSCAT Microscopy.

Gemeinhardt, A; McDonald, MP; Konig, K; Aigner, M; Mackensen, A; Sandoghdar, V

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Bone. 2018 Nov 13;120:254-261. doi: 10.1016/j.bone.2018.11.008. [Epub ahead of print]

Prediction of early metastatic disease in experimental breast cancer bone metastasis by combining PET/CT and MRI parameters to a Model-Averaged Neural Network.

Ellmann S, Seyler L, Evers J, Heinen H, Bozec A, Prante O, Kuwert T, Uder M, Bäuerle T

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PLoS One. 2018 Jul 16;13(7):e0200259. doi: 10.1371/journal.pone.0200259. eCollection 2018.

Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.

Schley G, Jordan J, Ellmann S, Rosen S, Eckardt KU, Uder M, Willam C, Bäuerle

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Mucosal Immunol. 2018 Nov 16. doi: 10.1038/s41385-018-0107-3. [Epub ahead of print]

Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths.

Schubart C, Krljanac B, Otte M, Symowski C, Martini E, Günther C, Becker C, Daniel C, Voehringer D.

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Mucosal Immunol. 2018 Nov;11(6):1621-1629. doi: 10.1038/s41385-018-0068-6. Epub 2018 Aug 13.

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells.

Ruder B, Murtadak V, Stürzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C8

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J Bone Miner Res. 2018 Nov;33(11):2035-2047. doi: 10.1002/jbmr.3533. Epub 2018 Jul 24.

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.

Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G.

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LEUKEMIA Volume:32 Issue:11 Pages:2445-2458 Published: NOV 2018     DOI: 10.1038/s41375-018-0114-0

Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway

Busch L, Mougiakakos D, Büttner-Herold M, Müller MJ, Volmer DA, Bach C, Fabri M, Bittenbring JT, Neumann F, Boxhammer R, Nolting J, Bisht S, Böttcher M, Jitschin S, Hoffmann MH, Balzer H, Beier F, Gezer D, Dudziak D, Gelse K, Hennig FH, Pallasch CP, Spriewald B, Mackensen A, Bruns H.

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Mol Cell Biol. 2018 Oct 29;38(22). pii: e00022-18. doi: 10.1128/MCB.00022-18. Print 2018 Nov 15.

Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin

Luo Y, Grötsch B, Hannemann N, Jimenez M, Ipseiz N, Uluckan O, Lin N, Schett G, Wagner EF, Bozec A.

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Nat Rev Rheumatol. 2018 Nov;14(11):631-640. doi: 10.1038/s41584-018-0091-8.

Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis.

Gravallese EM, Schett G.

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Bone. 2018 Nov;116:87-93. doi: 10.1016/j.bone.2018.07.017. Epub 2018 Jul 23.

A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the Skin

Simon D, Kleyer A, Englbrecht M, Stemmler F, Simon C, Berlin A, Kocijan R, Haschka J, Hirschmann S, Atreya R, Neurath MF, Sticherling M, Rech J, Hueber AJ, Engelke K, Schett G.

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Lancet Gastroenterol Hepatol. 2018 Nov;3(11):790-802. doi: 10.1016/S2468-1253(18)30265-6.

Mechanisms of molecular resistance and predictors of response to biological therapy in inflammatory bowel disease.

Atreya R, Neurath MF.

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PLoS One. 2018 Oct 26;13(10):e0206576. doi: 10.1371/journal.pone.0206576. eCollection 2018.

Application of machine learning algorithms for multiparametric MRI-based evaluation of murine colitis

Ellmann S, Langer V, Britzen-Laurent N, Hildner K, Huber C, Tripal P, Seyler L, Waldner M, Uder M, Stürzl M, Bäuerle T.

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 Gastroenterology. 2018 Oct 10. pii: S0016-5085(18)35154-0. doi: 10.1053/j.gastro.2018.10.023. [Epub ahead of print]

Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.

Tang Y, Reissig S, Glasmacher E, Regen T, Wanke F, Nikolaev A, Gerlach K, Popp V, Karram K, Fantini MC, Schattenberg JM, Galle PR, Neurath MF, Weigmann B, Kurschus FC, Hövelmeyer N, Waisman A

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Sci Rep. 2018 Oct 18;8(1):15453. doi: 10.1038/s41598-018-32476-1.

In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species

Bauwens E, Joosten M, Taganna J, Rossi M, Debraekeleer A, Tay A, Peters F, Backert S, Fox J, Ducatelle R, Remaut H, Haesebrouck F, Smet A.

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Front Immunol. 2018; 9: 2317. Published online 2018 Oct 16. doi: 10.3389/fimmu.2018.02317

Presence of Infected Gr-1(int)CD11b(hi)CD11c(int) Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice

Abdissa K, Nerlich A, Beineke A, Ruangkiattikul N, Pawar V, Heise U, Janze N, Falk C, Bruder D, Schleicher U, Bogdan C, Weiss S, Goethe R.

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Autoimmunity. 2018 Sep;51(6):281-287. doi: 10.1080/08916934.2018.1519804. Epub 2018 Oct 29. PMID:30369262

Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on Parade.

Podolska MJ, Mahajan A, Knopf J, Hahn J, Boeltz S, Munoz L, Bilyy R, Herrmann M.

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Autoimmunity. 2018 Sep;51(6):265-266,. doi: 10.1080/08916934.2018.1539839 . Published online 10 Dec 2018

Editorial – NETs in autoimmune diseases

Boeltz S & Herrmann M

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ISME J. 2018 Oct;12(10):2518-2531. doi: 10.1038/s41396-018-0199-5. Epub 2018 Jun 25.

Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

Smet A1,2, Yahara K3, Rossi M4, Tay A5, Backert S6, Armin E7, Fox JG8, Flahou B9, Ducatelle R9, Haesebrouck F9, Corander J10,11,12.

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ISME J. 2018 Oct;12(10):2518-2531. doi: 10.1038/s41396-018-0199-5. Epub 2018 Jun 25.

Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

Smet A1,2, Yahara K3, Rossi M4, Tay A5, Backert S6, Armin E7, Fox JG8, Flahou B9, Ducatelle R9, Haesebrouck F9, Corander J10,11,12.

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Free Radic Biol Med. 2018 Sep;125:62-71. doi: 10.1016/j.freeradbiomed.2018.03.016. Epub 2018 Mar 15.

The dual role of Reactive Oxygen Species in autoimmune and inflammatory diseases: evidence from preclinical models

Hoffmann MH1, Griffiths HR2.

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ARTHRITIS RESEARCH & THERAPY  Volume: 20     Published: AUG 30 2018      DOI: 10.1186/s13075-018-1620-1 

Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis.

Neumann, A; Haschka, J; Kleyer, A; Schuster, L; Englbrecht, M; Berlin, A; Figueiredo, CP; Simon, D; Muschitz, C; Kocijan, R; Resch, H; Rech, J; Schett, G

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ARTHRITIS RESEARCH & THERAPY . 2018  Volume: 20     Published: AUG 31 2018      doi: 10.1186/s13075-018-1691-z

Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis – effects of age and disease duration

Simon, D; Kleyer, A; Faustini, F; Englbrecht, M; Haschka, J; Berlin, A; Kraus, S; Hueber, AJ; Kocijan, R; Sticherling, M; Rech, J; Schett, G

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MICROORGANISMS 2018 Volume: 6     Issue: 2     Published: JUN 2018      doi: 10.3390/microorganisms6020044

Binding of Helicobacter pylori to Human Gastric Mucins Correlates with Binding of TFF1

Dunne, C; Naughton, J; Duggan, G; Loughrey, C; Kilcoyne, M; Joshi, L; Carrington, S; Earley, H; Backert, S; Masselot, CR; May, FEB; Clyne, M

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J Cell Mol Med. 2018 Sep;22(9):4399-4409. doi: 10.1111/jcmm.13735. Epub 2018 Jul 11.

The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis.

Fischer A, Abdollahi-Roodsaz S, Böhm C, Niederreiter B, Meyer B, Yau ACY, Lönnblom E, Joosten LAB, Koenders M, Lehmann CHK, Dudziak D, Krönke G, Holmdahl R, Steiner G.

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Nat Commun. 2018 Aug 15;9(1):3261. doi: 10.1038/s41467-018-05800-6

Resolution of chronic inflammatory disease: universal and tissue-specific concepts.

Schett G, Neurath MF.

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Ann Rheum Dis. 2018 Aug 17. pii: annrheumdis-2018-213223. doi: 10.1136/annrheumdis-2018-213223. [Epub ahead of print]

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation.

Pieterse E, Rother N, Yanginlar C, Gerretsen J, Boeltz S, Munoz LE, Herrmann M, Pickkers P, Hilbrands LB, van der Vlag J.
Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3.

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.

Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW.
Front. Immunol. 2018 July 31. doi.org/10.3389/fimmu.2018.01700

Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases

Rath T, Billmeier U, Ferrazzi F, Vieth M, Ekici A, Neurath MF,  Atreya R.
Bone. 2018 Jul 23;116:87-93. doi: 10.1016/j.bone.2018.07.017. [Epub ahead of print]

A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin.

Simon D, Kleyer A, Englbrecht M, Stemmler F, Simon C, Berlin A, Kocijan R, Haschka J, Hirschmann S, Atreya R, Neurath MF, Sticherling M, Rech J, Hueber AJ, Engelke K, Schett G.

 Dis Model Mech. 2018 Jul 25. pii: dmm.034041. doi: 10.1242/dmm.034041. [Epub ahead of print]

A model of chronic enthesitis and new bone formation characterized by multimodal imaging.

Czegley C, Gillmann C, Schauer C, Seyler L, Reinwald C, Hahn M, Uder M, Jochmann K, Naschberger E, Stock M, Schett G, Bäuerle T, Hoffmann MH.
Cell Rep. 2018 Jul 3;24(1):169-180. doi: 10.1016/j.celrep.2018.06.005.

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM.
J Bone Miner Res. 2018 Jun 27. doi: 10.1002/jbmr.3533. [Epub ahead of print]

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.

Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G.
JCI Insight. 2018 Jun 7;3(11). pii: 99712. doi: 10.1172/jci.insight.99712. [Epub ahead of print]

CD83 expression is essential for Treg cell differentiation and stability.

Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Baßler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, Wirtz S, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M.
Gut. 2018 May 30. pii: gutjnl-2017-315671. doi: 10.1136/gutjnl-2017-315671. [Epub ahead of print]

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease.

Schmitt H, Billmeier U, Dieterich W, Rath T, Sonnewald S, Reid S, Hirschmann S, Hildner K, Waldner MJ, Mudter J, Hartmann A, Grützmann R, Neufert C, Münster T, Neurath MF, Atreya R.
Front Immunol. 2018 May 25;9:1138. doi: 10.3389/fimmu.2018.01138. eCollection 2018.

Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis.

Buchele V, Abendroth B, Büttner-Herold M, Vogler T, Rothamer J, Ghimire S, Ullrich E, Holler E, Neurath MF, Hildner K.
Front Immunol. 2018 May 7;9:989. doi: 10.3389/fimmu.2018.00989. eCollection 2018.

Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus.

Biermann MHC, Boeltz S, Pieterse E, Knopf J, Rech J, Bilyy R, van der Vlag J, Tincani A, Distler JHW, Krönke G, Schett GA, Herrmann M, Muñoz LE.
Sci Transl Med. 2018 Jan 3;10(422). pii: eaag1782. doi: 10.1126/scitranslmed.aag1782.

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.

Serr I, Scherm MG, Zahm AM, Schug J, Flynn VK, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, Gerlach K, Liebsch N, Loretz B, Lehr CM, Kirchner B, Spornraft M, Haase B, Segars J, Küper C, Palmisano R, Waisman A, Willis RA, Kim WU, Weigmann B, Kaestner KH, Ziegler AG, Daniel C.
Front Immunol. 2018 Feb 5;9:79. doi: 10.3389/fimmu.2018.00079. eCollection 2018.

Type I interferon Signaling is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection.

Schleicher U, Liese J, Justies N, Mischke T, Haeberlein S, Sebald H, Kalinke U, Weiss S, Bogdan C.
Cell Syst. 2018 Jul 25;7(1):41-48.e5. doi: 10.1016/j.cels.2018.05.018. Epub 2018 Jun 27.

Dissecting Fc gamma R Regulation through a Multivalent Binding Model.

Robinett RA, Guan N, Lux A, Biburger M, Nimmerjahn F, Meyer AS.
Int J Med Microbiol. 2017 Sep 14. pii: S1438-4221(17)30318-1. doi: 10.1016/j.ijmm.2017.09.010. [Epub ahead of print]

Coxiella burnetii as a useful tool to investigate bacteria-friendly host cell compartments.

Pechstein, J., Schulze-Luehrmann, J. & Luhrmann, A.
J Vis Exp. 2018 Sep 20;(139). doi: 10.3791/58210.

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease.

Becker E1, Schramm S1, Binder MT1, Allner C1, Wiendl M1, Neufert C1, Atreya I1, Neurath M1, Zundler S2.
Inflamm Bowel Dis. 2018 May 18;24(6):1237-1250. doi: 10.1093/ibd/izy077.

Similar Inhibition of Dynamic Adhesion of Lymphocytes From IBD Patients to MAdCAM-1 by Vedolizumab and Etrolizumab-s.

Binder MT1, Becker E1, Wiendl M1, Schleier L1, Fuchs F1, Leppkes M1, Atreya R1, Neufert C1, Atreya I1, Neurath MF1, Zundler S1.
Front Immunol. 2018 Mar 16;9:535. doi: 10.3389/fimmu.2018.00535. eCollection 2018.

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.

Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F.
Front Immunol. 2018 Mar 28;9:644. doi: 10.3389/fimmu.2018.00644. eCollection 2018.

A 17-kDa Fragment of Lactoferrin Associates With the Termination of Inflammation and Peptides Within Promote Resolution.

Lutaty A, Soboh S, Schif-Zuck S, Zeituni-Timor O, Rostoker R, Podolska MJ, Schauer C, Herrmann M, Muñoz LE, Ariel A.
J Neuroimmunol. 2018 Jul 15;320:19-24. doi: 10.1016/j.jneuroim.2018.04.010. Epub 2018 Apr 16.

Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG.

Knopf J1, Magorivska I2, Maler JM3, Spitzer P3, Bilyy R4, Biermann MHC1, Hychka K4, Bondt A5, Wuhrer M6, Toes REM7, Schett G1, Herrmann M1, Muñoz LE8.
Semin Immunopathol. 2018 Jul;40(4):379-392. doi: 10.1007/s00281-018-0677-x. Epub 2018 Mar 26.

ILC2s in infectious diseases and organ-specific fibrosis.

Kindermann, M., Knipfer, L., Atreya, I. & Wirtz, S.
Front Immunol. 2018 Apr 27;9:744. doi: 10.3389/fimmu.2018.00744. eCollection 2018.

CLEC10A Is a Specific Marker for Human CD1c(+) Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.

Heger L1, Balk S1, Lühr JJ1, Heidkamp GF1, Lehmann CHK1, Hatscher L1, Purbojo A2, Hartmann A3, Garcia-Martin F4, Nishimura SI4, Cesnjevar R2, Nimmerjahn F5, Dudziak D1.
Mucosal Immunol. 2018 Jul;11(4):1191-1202. doi: 10.1038/s41385-018-0011-x. Epub 2018 Mar 8.

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis.

Hefele M1, Stolzer I1, Ruder B1, He GW1, Mahapatro M1, Wirtz S1, Neurath MF1, Günther C2.
Matrix Biol. 2018 Aug;68-69:8-27. doi: 10.1016/j.matbio.2017.12.016. Epub 2018 Jan 31.

Targeting TGF-beta signaling for the treatment of fibrosis.

Gyorfi, A.H., Matei, A.E. & Distler, J.H.W.
Front Immunol. 2017; 8: 1876. Published online 2018 Jan 17. doi:  10.3389/fimmu.2017.01876

Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro.

Gerhard E. Grossmayer,1 Hildegard Keppeler,2 Sebastian Boeltz,1 Christina Janko,1,3 Jürgen Rech,1 Martin Herrmann,1 Kirsten Lauber,4,* and Luis E. Muñoz1,
J Immunol. 2018 Feb 1;200(3):983-996. doi: 10.4049/jimmunol.1701180. Epub 2017 Dec 20.

Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.

Friede, M.E., Leibelt, S., Dudziak, D. & Steinle, A.
Semin Arthritis Rheum. 2018 Apr;47(5):611-618. doi: 10.1016/j.semarthrit.2017.09.011. Epub 2017 Sep 23.

Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT).

Figueiredo CP1, Kleyer A2, Simon D2, Stemmler F2, d’Oliveira I2, Weissenfels A3, Museyko O3, Friedberger A3, Hueber AJ2, Haschka J4, Englbrecht M2, Pereira RMR5, Rech J2, Schett G2, Engelke K6.
Blood. 2018 May 17;131(20):2205-2214. doi: 10.1182/blood-2017-12-822908. Epub 2018 Mar 27.

Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia.

Blumberg RS1,2, Lillicrap D3; Nimmerjahn, F., IgG Fc Immune Tolerance Group.

Arthritis Res Ther. 2018 May 2;20(1):84. doi: 10.1186/s13075-018-1586-z.

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.

Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL, Nimmerjahn F, Krönke G, Scherer HU, Forsblad-d’Elia H, Schett G.
Ann Rheum Dis. 2018 Jul;77(7):973-980. doi: 10.1136/annrheumdis-2017-212404. Epub 2018 Feb 23.

Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures.

Stemmler F, Simon D, Liphardt AM, Englbrecht M, Rech J, Hueber AJ, Engelke K, Schett G, Kleyer A.
Eur J Immunol. 2018 May;48(5):822-828. doi: 10.1002/eji.201747227. Epub 2018 Mar 5.

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

Haberland K, Ackermann JA, Ipseiz N, Culemann S, Pracht K, Englbrecht M, Jäck HM, Schett G, Schuh W, Krönke G.
J Clin Invest. 2018 Mar 1;128(3):916-930. doi: 10.1172/JCI89242. Epub 2018 Jan 29.

BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.

Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.
Curr Top Microbiol Immunol. 2017;413:243-268. doi: 10.1007/978-3-319-75241-9_10.

Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Pathogenesis.

Pechstein J, Schulze-Luehrmann J, Lührmann A.
Int J Med Microbiol. 2017 Sep 14. pii: S1438-4221(17)30318-1. doi: 10.1016/j.ijmm.2017.09.010. [Epub ahead of print]

Coxiella burnetii as a useful tool to investigate bacteria-friendly host cell compartments.

Lührmann A, Newton HJ, Bonazzi M.
Nat Rev Rheumatol. 2018 Mar;14(3):157-169. doi: 10.1038/nrrheum.2018.10. Epub 2018 Feb 8.

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

Scherer HU, Huizinga TWJ, Krönke G, Schett G, Toes REM.
Arthritis Res Ther. 2018 Feb 7;20(1):24. doi: 10.1186/s13075-018-1527-x.

Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokineproduction in human macrophages in IDO-dependent manner.

Bozec ALuo YEngdahl CFigueiredo CBang H, Schett G.
Nat Commun. 2018 Jan 17;9(1):251. doi: 10.1038/s41467-017-02683-x.

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.

Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A.
J Immunol. 2018 Jan 12. pii: ji1700596. doi: 10.4049/jimmunol.1700596. [Epub ahead of print]

Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis.

Soare A, Weber S, Maul L, Rauber S, Gheorghiu AM, Luber M, Houssni I, Kleyer A, von Pickardt G, Gado M, Simon D, Rech J, Schett G, Distler JHW, Ramming A.
Ann Rheum Dis. 2018 Jan 8. pii: annrheumdis-2017-212489. doi: 10.1136/annrheumdis-2017-212489. [Epub ahead of print]

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.

Matei AE, Beyer C, Györfi AH, Soare A, Chen CW, Dees C, Bergmann C, Ramming A, Friebe A, Hofmann F, Distler O, Schett G, Distler JHW.
Nat Commun. 2018 Jan 4;9(1):55. doi: 10.1038/s41467-017-02490-4.

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.

Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM.
Front Microbiol. 2018 Apr 16;9:642. doi: 10.3389/fmicb.2018.00642. eCollection 2018.

Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation.

Albrecht N1, Tegtmeyer N1, Sticht H2, Skórko-Glonek J3, Backert S1.
Cell Microbiol. 2018 Jun;20(6):e12845. doi: 10.1111/cmi.12845. Epub 2018 Apr 30.

Extracellular HtrA serine proteases: An emerging new strategy in bacterial pathogenesis.

Backert S1, Bernegger S2, Skórko-Glonek J3, Wessler S2.
Mol Microbiol. 2018 Feb;107(4):455-471. doi: 10.1111/mmi.13896. Epub 2018 Jan 18.

Type IV secretion in Gram-negative and Gram-positive bacteria.

Grohmann, E., Christie, P.J., Waksman, G. & Backert, S.
Front Immunol. 2018; 9: 1171. Published online 2018 May 30. doi:  10.3389/fimmu.2018.01171

Editorial: Immune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing.

Leppkes, M., Siegmund, B. & Becker, C.
Nano Lett. 2018 Jan 10;18(1):513-519. doi: 10.1021/acs.nanolett.7b04494. Epub 2017 Dec 19.

Visualizing Single-Cell Secretion Dynamics with Single-Protein Sensitivity.

McDonald MP1, Gemeinhardt A1, König K1,2, Piliarik M1, Schaffer S3, Völkl S3, Aigner M3, Mackensen A3, Sandoghdar V1,2.
Front Immunol. 2018 Jan 24;9:24. doi: 10.3389/fimmu.2018.00024. eCollection 2018.

Monocyte-Derived signals activate human natural Killer cells in response to Leishmania Parasites.

Messlinger H, Sebald H, Heger L, Dudziak D, Bogdan C, Schleicher U.
EMBO J. 2018 Jul 2;37(13). pii: e98665. doi: 10.15252/embj.201798665. Epub 2018 Jun 1.

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs.

Moonens K1,2, Hamway Y3, Neddermann M4, Reschke M5, Tegtmeyer N4, Kruse T6, Kammerer R7, Mejías-Luque R3,8, Singer BB5, Backert S4, Gerhard M3,8, Remaut H9,2.
Br J Dermatol. 2018 Mar;178(3):740-748. doi: 10.1111/bjd.15867. Epub 2018 Jan 22.

The genetic basis for most patients with pustular skin disease remains elusive.

Mössner R, Wilsmann-Theis D, Oji V, Gkogkolou P, Löhr S, Schulz P, Körber A6, Prinz JC7, Renner R8, Schäkel K9, Vogelsang L9, Peters KP10, Philipp S11, Reich K12, Ständer H13, Jacobi A14, Weyergraf A5, Kingo K15, Kõks S16, Gerdes S17, Steinz K17, Schill T2, Griewank KG6, Müller M18, Frey S19, Ebertsch L4, Uebe S4, Sticherling M8, Sticht H20, Hüffmeier U4.
Gastroenterology. 2018 Nov 16. pii: S0016-5085(18)35277-6. doi: 10.1053/j.gastro.2018.11.029. [Epub ahead of print]

Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation.

Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C.
Gastroenterology. 2018 Mar;154(4):807-809.e3. doi: 10.1053/j.gastro.2017.11.285. Epub 2018 Jan 5.

Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution.

Knieling F, Gonzales Menezes J, Claussen J, Schwarz M, Neufert C, Fahlbusch FB, Rath T, Thoma OM, Kramer V, Menchicchi B, Kersten C, Scheibe K, Schürmann S, Carlé B, Rascher W, Neurath MF, Ntziachristos V, Waldner MJ.
Gastroenterology. 2018 Mar;154(4):778-783. doi: 10.1053/j.gastro.2018.01.009. Epub 2018 Jan 11.

Heptose 1,7-Bisphosphate Directed TIFA Oligomerization: A Novel PAMP-Recognizing Signaling Platform in the Control of Bacterial Infections.

Pachathundikandi, K. & Backert, S.
Innate Immun. 2018 Jan;24(1):11-23. doi: 10.1177/1753425917738043. Epub 2017 Nov 16.

Helicobacter pylori controls NLRP3 expression by regulating hsa-miR-223-3p and IL-10 in cultured and primary human immune cells.

Pachathundikandi, S.K. & Backert, S.
Front Immunol. 2018; 9: 1827. Published online 2018 Aug 13. doi:  10.3389/fimmu.2018.01827

Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils.

Viktor Reshetnikov,1 Jonas Hahn,2 Christian Maueröder,3,4 Christine Czegley,2 Luis Enrique Munoz,2 Martin Herrmann,2 Markus H. Hoffmann,2,* and Andriy Mokhir1,*

2017

Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897.

Host DNases prevent vascular occlusion by neutrophil extracellular traps.

Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA.

Mehr

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

[…] Hahn J, […] Herrmann M, […] Maueröder C, […] Mielenz D,[…], Munoz LE,[…] Vöhringer D, […] Zhao Y, […]

Mehr

Gastroenterology 2017 Oct;153(4):898-900. DOI: 10.1053/j.gastro.2017.07.022

Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut.

Zundler S, Klingberg A, Schillinger D, Fischer S, Neufert C, Atreya I, Gunzer M, Neurath MF.

Mehr

Immunol Rev. 2017 Nov;280(1):26-40. doi: 10.1111/imr.12569.

Missing in action-The meaning of cell death in tissue damage and inflammation.

Muñoz LE, Leppkes M, Fuchs TA, Hoffmann M, Herrmann M.

Mehr

Nat Commun. 2017 Oct 24;8(1):1130. 8(1):1130. doi: 10.1038/s41467-017-01236-6.

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis.

Chakraborty D, Šumová B, Mallano T, Chen CW, Distler A, Bergmann C, Ludolph I, Horch RE, Gelse K, Ramming A, Distler O, Schett G, Šenolt L, Distler JHW.

Mehr

Ann Rheum Dis. 2017 Oct 25. pii: annrheumdis-2017-211501. doi: 10.1136/annrheumdis-2017-211501.

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis.

Bergmann C, Brandt A, Merlevede B, Hallenberger L, Dees C, Wohlfahrt T, Pötter S, Zhang Y, Chen CW, Mallano T, Liang R, Kagwiria R, Kreuter A, Pantelaki I, Bozec A, Abraham D, Rieker R, Ramming A, Distler O, Schett G, Distler JHW.

Mehr

Nat Rev Rheumatol. 2017 Nov 21;13(12):731-741. doi: 10.1038/nrrheum.2017.188.

Enthesitis: from pathophysiology to treatment.

Schett G, Lories RJ, D’Agostino MA, Elewaut D, Kirkham B, Soriano ER, McGonagle D.

Ann Rheum Dis. 2017 Sep 19.pii: annrheumdis-2017-211687. doi: 10.1136/annrheumdis-2017-211687.

The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study.

Schönau V, Vogel K, Englbrecht M, Wacker J, Schmidt D, Manger B, Kuwert T, Schett G.

Mehr

Cell Host Microbe. 2017 Oct 11;22(4):552-560.e5. doi: 10.1016/j.chom.2017.09.005.

Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery.

Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S.

Mehr

Front. Immunol., 28 July 2017 | https://doi.org/10.3389/fimmu.2017.00874

Neutrophil Extracellular Traps Open the Pandora’s Box in Severe Malaria

Boeltz S, Muñoz L, Fuchs T, Herrmann M.

Current Opinion in Rheumatology. 29(2):208–213, MAR 2017 DOI: 10.1097/BOR.0000000000000361

The novel interleukin-1 cytokine family members in inflammatory diseases.

Hahn M, Frey S, Hueber AJ.
Front. Immunol., 28 June 2017 | https://doi.org/10.3389/fimmu.2017.00722

Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction

Kurow O, Frey B, Schuster L, Schmitt V, Adam S, Hahn M, Gilchrist D, McInnes I, Wirtz S, Gaipl U, Krönke G, Schett G, Frey S, Hueber AJ.
Eur J Immunol. 2017 Aug 31. doi: 10.1002/eji.201646788.

Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.

Schmitt V, Hahn M, Kästele V, Wagner O, Wiendl M, Derer A, Taddeo A, Hahne S, Radbruch A, Jäck HM, Schuh W, Mielenz D, Gay S, Schett G, Hueber AJ, Frey S.
Br J Dermatol. 2017 Aug 5. doi: 10.1111/bjd.15867.

The genetic basis for most patients with pustular skin disease remains elusive.

Mössner R, Wilsmann-Theis D, Oji V, Gkogkolou P, Löhr S, Schulz P, Körber A, Christoph-Prinz J, Renner R, Schäkel K, Vogelsang L, Peters KP, Philipp S, Reich K, Ständer H, Jacobi A, Weyergraf A, Kingo K, Kõks S, Gerdes S, Steinz K, Schill T, Griewank KG, Müller M, Frey S, Ebertsch L, Uebe S, Sticherling M, Sticht H, Hüffmeier U.
Nat Med. 2017 Jul 17. doi: 10.1038/nm.4373.

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells.

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A.
J Exp Med. 2017 Jul 3;214(7):2121-2138. doi: 10.1084/jem.20161070. Epub 2017 May 31.

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O’Donnell VB, Krönke G.
J Exp Med. 2017 Jul 3;214(7):2059-2071. doi: 10.1084/jem.20160514. Epub 2017 May 31.

Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription.

Ubieta K, Garcia M, Grötsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D, Bozec A.
J Clin Invest. 2017 Jun 1;127(6):2030-2039. doi: 10.1172/JCI93356. Epub 2017 Jun 1.

Inflammatory osteolysis: a conspiracy against bone.

Mbalaviele G, Novack DV, Schett G, Teitelbaum SL.
JCI Insight. 2017 May 18;2(10). pii: 92920. doi: 10.1172/jci.insight.92920. [Epub ahead of print]

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH.
Clin Exp Immunol. 2017 May 16. doi: 10.1111/cei.12987. [Epub ahead of print]

Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during therapy.

Stümer J, Biermann MHC, Knopf J, Magorivska I, Kastbom A, Svärd A, Janko C, Bilyy R, Schett G, Sjöwall C, Herrmann M, Muñoz LE.
Arthritis Rheumatol. 2017 May 10. doi: 10.1002/art.40148. [Epub ahead of print]

Early Changes of the Cortical Micro-Channel System in the Bare Area of the Joints of Patients With Rheumatoid Arthritis.

Werner D, Simon D, Englbrecht M, Stemmler F, Simon C, Berlin A, Haschka J, Renner N, Buder T, Engelke K, Hueber AJ, Rech J, Schett G, Kleyer A.
Ann Rheum Dis. 2017 Aug;76(8):1467-1475. doi: 10.1136/annrheumdis-2016-210911. Epub 2017 May 6.

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment.

Zhang Y, Liang R, Chen CW, Mallano T, Dees C, Distler A, Reich A, Bergmann C, Ramming A, Gelse K, Mielenz D, Distler O, Schett G, Distler JHW.
J Exp Med. 2017 Jun 5;214(6):1655-1662. doi: 10.1084/jem.20160442. Epub 2017 May 5.

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.

He GW, Günther C, Thonn V, Yu YQ, Martini E, Buchen B, Neurath MF, Stürzl M, Becker C.
J Immunol. 2017 May 15;198(10):3878-3885. doi: 10.4049/jimmunol.1600638. Epub 2017 Apr 14.

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation.

Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Krönke G.
J Immunol. 2017 May 1;198(9):3436-3447. doi: 10.4049/jimmunol.1601716. Epub 2017 Mar 17.

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.

Binder N, Miller C, Yoshida M, Inoue K, Nakano S, Hu X, Ivashkiv LB, Schett G, Pernis A, Goldring SR, Ross FP, Zhao B.
J Immunol. 2017 May 1;198(9):3605-3614. doi: 10.4049/jimmunol.1601330. Epub 2017 Mar 15.

The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages.

Hannemann N, Jordan J, Paul S, Reid S, Baenkler HW, Sonnewald S, Bäuerle T, Vera J, Schett G, Bozec A.
J Exp Med. 2017 May 1;214(5):1509-1528. doi: 10.1084/jem.20160951. Epub 2017 Apr 7.

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D.
J Immunol. 2017 Mar 15;198(6):2394-2402. doi: 10.4049/jimmunol.1601472. Epub 2017 Feb 10.

Neurodegeneration Enhances the Development of Arthritis.

Lang SC, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J,Baum W, Herrmann M, Schett G, Mielenz D.
J Bone Miner Res. 2017 Apr 20. doi: 10.1002/jbmr.3158. [Epub ahead of print]

Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin.

Engdahl C, Bang H, Dietel K, Lang SC, Harre U, Schett G.
J Immunol. 2017 Mar 15;198(6):2286-2301. doi: 10.4049/jimmunol.1600802. Epub 2017 Feb 13.

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes.

Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.
Gastroenterology. 2017 Jan;152(1):176-192.e5. doi: 10.1053/j.gastro.2016.09.005. Epub 2016 Sep 14.

Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.

Popp V, Gerlach K, Mott S, Turowska A, Garn H, Atreya R, Lehr HA, Ho IC, Renz H, Weigmann B, Neurath MF.
Autoimmunity. 2017 May;50(3):151-157. doi: 10.1080/08916934.2016.1261837. Epub 2017 Jan 13.

Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites.

Sarter K, Kulagin M, Schett G, Harris NL, Zaiss MM.
Semin Arthritis Rheum. 2017 Jun;46(6):709-714. doi: 10.1016/j.semarthrit.2016.09.011. Epub 2016 Oct 3.

Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients-A longitudinal analysis.

Wunderlich, C., Oliviera, I., Figueiredo, C.P., Rech, J. & Schett, G.
Nat Protoc. 2017 Jul;12(7):1295-1309. doi: 10.1038/nprot.2017.044. Epub 2017 Jun 1.

Chemically induced mouse models of acute and chronic intestinal inflammation.

Wirtz S1, Popp V1, Kindermann M1, Gerlach K1, Weigmann B1, Fichtner-Feigl S2, Neurath MF1.
J Bone Miner Res. 2017 Apr;32(4):722-730. doi: 10.1002/jbmr.3025. Epub 2016 Nov 18.

Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis.

Simon D1, Kleyer A1, Stemmler F1, Simon C1, Berlin A1, Hueber AJ1, Haschka J2, Renner N3, Figueiredo C1,4, Neuhuber W5, Buder T5, Englbrecht M1, Rech J1, Engelke K6, Schett G1.
Nat Rev Rheumatol. 2017 Oct;13(10):621-630. doi: 10.1038/nrrheum.2017.146. Epub 2017 Sep 14.

Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

Seeling, M., Bruckner, C. & Nimmerjahn, F.
Gut. 2017 Nov;66(11):1936-1948. doi: 10.1136/gutjnl-2016-312439. Epub 2016 Aug 19.

Blockade of αEβ7 integrin suppresses accumulation of CD8+ and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.

Zundler S1, Schillinger D1, Fischer A1, Atreya R1, López-Posadas R1, Watson A2, Neufert C1, Atreya I1, Neurath MF1.
Inflamm Bowel Dis. 2017 Mar;23(3):379-391. doi: 10.1097/MIB.0000000000001029.

The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohn’s Disease Effector T Cells In Vivo.

Zundler S1, Fischer A, Schillinger D, Binder MT, Atreya R, Rath T, Lopez-Pósadas R, Voskens CJ, Watson A, Atreya I, Neufert C, Neurath MF.
Front Immunol. 2017; 8: 764. Published online 2017 Jul 3. doi: 10.3389/fimmu.2017.00764

Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles

Friederike Fuchs,1,† Daniela Schillinger,1,† Raja Atreya,1 Simon Hirschmann,1 Sarah Fischer,1 Clemens Neufert,1 Imke Atreya,1 Markus F. Neurath,1,‡ and Sebastian Zundler1,*‡
J Immunol. 2017 Jul 1;199(1):172-185. doi: 10.4049/jimmunol.1601533. Epub 2017 May 26.

 The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.

Schneppenheim J1,2, Loock AC1, Hüttl S1, Schweizer M3, Lüllmann-Rauch R2, Oberg HH4, Arnold P2, Lehmann CHK5, Dudziak D5,6, Kabelitz D4, Lucius R2, Lennon-Duménil AM7, Saftig P1, Schröder B8.
J Med Chem. 2017 Feb 9;60(3):941-956. doi: 10.1021/acs.jmedchem.6b01111. Epub 2017 Jan 19.

Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion.

Prescher H1, Frank M2, Gütgemann S, Kuhfeldt E1, Schweizer A3, Nitschke L3, Watzl C, Brossmer R1.
Front Immunol. 2017 Oct 20;8:1318. doi: 10.3389/fimmu.2017.01318. eCollection 2017.

Editorial: NEtosis 2: the Excitement Continues.

Muñoz LE1, Kaplan MJ2, Radic M3, Herrmann M1.
J Immunol. 2017 May 1;198(9):3737-3745. doi: 10.4049/jimmunol.1601838. Epub 2017 Mar 27.

Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis.

Mokada-Gopal L1, Boeser A2, Lehmann CHK3, Drepper F2,4, Dudziak D3, Warscheid B2,4, Voehringer D5.
Exp. Dermatol. 26, 691-696 (2017). doi: 10.1111/exd.13163

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury.

Sidonia Mihai, Heike Albert, Ralf J. Ludwig, Hiroaki Iwata, Lars Björck, Mattias Collin, Falk Nimmerjahn
Front Immunol. 2017 Jan 27;8:16. doi: 10.3389/fimmu.2017.00016. eCollection 2017.

Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide.

Maueröder C1, Schall N2, Meyer F2, Mahajan A1, Garnier B2, Hahn J1, Kienhöfer D1, Hoffmann MH1, Muller S3.
Trends Immunol. 2017 Jan;38(1):29-38. doi: 10.1016/j.it.2016.10.004. Epub 2016 Oct 31.

Friend or Foe? The Ambiguous Role of Innate Lymphoid Cells in Cancer Development.

Mattner, J. & Wirtz, S.
Front Immunol. 2017 May 31;8:603. doi: 10.3389/fimmu.2017.00603. eCollection 2017.

Mechanisms of Autoantibody-Induced Pathology.

Ludwig RJ1, Vanhoorelbeke K2, Leypoldt F3,4,5, Kaya Z6, Bieber K1, McLachlan SM7, Komorowski L8, Luo J9, Cabral-Marques O10, Hammers CM11, Lindstrom JM9, Lamprecht P10, Fischer A6, Riemekasten G10, Tersteeg C2, Sondermann P12, Rapoport B7, Wandinger KP13, Probst C8, El Beidaq A14, Schmidt E1, Verkman A15,16, Manz RA14, Nimmerjahn F17.
Infect Immun. 2017 Jul 19;85(8). pii: e00084-17. doi: 10.1128/IAI.00084-17. Print 2017 Aug.

Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway.

Leitherer S1, Clos J2, Liebler-Tenorio EM3, Schleicher U1,4, Bogdan C1,4, Soulat D5,4.
Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12.

IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.

Lee CH1, Romain G2, Yan W3, Watanabe M1, Charab W1, Todorova B4,5, Lee J1, Triplett K3, Donkor M1, Lungu OI1, Lux A6, Marshall N1, Lindorfer MA7, Goff OR4,5, Balbino B4,5,8, Kang TH1, Tanno H1, Delidakis G1, Alford C9, Taylor RP7, Nimmerjahn F6, Varadarajan N2, Bruhns P4,5, Zhang YJ3,10, Georgiou G1
Front Biosci (Landmark Ed). 2017 Jun 1;22:1581-1598.

The role of lipids in host microbe interactions.

Lang, R.L. & Mattner, J
Eur J Immunol. 2017 Dec;47(12):2070-2079. doi: 10.1002/eji.201747208. Epub 2017 Aug 29.

IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.

Kao D1, Lux A1, Schaffert A1, Lang R2, Altmann F3, Nimmerjahn F1.
Cell Metab. 2017 Sep 5;26(3):475-492.e7. doi: 10.1016/j.cmet.2017.08.008.

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.

Kälin S1, Becker M2, Ott VB3, Serr I2, Hosp F4, Mollah MMH2, Keipert S1, Lamp D1, Rohner-Jeanrenaud F5, Flynn VK2, Scherm MG2, Nascimento LFR2, Gerlach K6, Popp V6, Dietzen S7, Bopp T7, Krishnamurthy P8, Kaplan MH8, Serrano M9, Woods SC10, Tripal P11, Palmisano R11, Jastroch M1, Blüher M12, Wolfrum C13, Weigmann B6, Ziegler AG14, Mann M4, Tschöp MH15, Daniel C16.
Gut. 2017 Apr;66(4):716-723. doi: 10.1136/gutjnl-2015-311247. Epub 2016 Aug 26.

PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.

He GW1, Günther C1, Kremer AE1, Thonn V1, Amann K2, Poremba C3, Neurath MF1, Wirtz S1, Becker C1.
Front Immunol. 2017; 8: 1922. Published online 2017 Dec 22. doi:  10.3389/fimmu.2017.01922

Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells.

Anna Hammer,1, Anne Waschbisch,1, Ilka Knippertz,2,3 Elisabeth Zinser,2,3 Johannes Berg,4 Stefanie Jörg,1 Kristina Kuhbandner,1 Christina David,4 Jingbo Pi,5 Antonios Bayas,6 De-Hyung Lee,1 Aiden Haghikia,4 Ralf Gold,4 Alexander Steinkasserer,2,3 and Ralf A. Linker1,*

 Curr Opin Microbiol. 2017 Feb;35:88-99. doi: 10.1016/j.mib.2017.03.001. Epub 2017 Mar 19.

Modulation of host cell apoptotic pathways by intracellular pathogens.

Friedrich A1, Pechstein J2, Berens C3, Lührmann A4.

 Ann Rheum Dis. 2017 Feb;76(2):399-407. doi: 10.1136/annrheumdis-2016-209297. Epub 2016 Jun 20.

Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs

Figueiredo CP1,2, Bang H3, Cobra JF4, Englbrecht M1, Hueber AJ1, Haschka J5, Manger B1, Kleyer A1, Reiser M1, Finzel S1, Tony HP6, Kleinert S7, Wendler J7, Schuch F7, Ronneberger M7, Feuchtenberger M8, Fleck M9, Manger K10, Ochs W11, Schmitt-Haendle M11, Lorenz HM12,13, Nuesslein H14, Alten R15, Henes J16, Krueger K17, Rech J1, Schett G1.

 Gastroenterology. 2017 Jul;153(1):123-138.e8. doi: 10.1053/j.gastro.2017.03.015. Epub 2017 Mar 23.

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease.

Chiriac MT1, Buchen B2, Wandersee A2, Hundorfean G2, Günther C2, Bourjau Y2, Doyle SE3, Frey B4, Ekici AB5, Büttner C5, Weigmann B2, Atreya R6, Wirtz S2, Becker C2, Siebler J2, Neurath MF7.
Nat Rev Rheumatol. 2017 Feb;13(2):79-86. doi: 10.1038/nrrheum.2016.200. Epub 2016 Dec 15.

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis.

Catrina AI1, Svensson CI2, Malmström V1, Schett G3, Klareskog L1.
Am J Pathol. 2017 May;187(5):1106-1120. doi: 10.1016/j.ajpath.2017.01.012. Epub 2017 Apr 12.

CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function.

Buchheister S1, Buettner M1, Basic M1, Noack A2, Breves G3, Buchen B4, Keubler LM1, Becker C4, Bleich A5.
Int Immunol. 2017 Dec 30;29(11):499-509. doi: 10.1093/intimm/dxx053.

Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation.

Brückner, C., Lehmann, C., Dudziak, D. & Nimmerjahn, F.
Curr Osteoporos Rep. 2017 Jun;15(3):121-125. doi: 10.1007/s11914-017-0356-1.

T Regulatory Cells in Bone Remodelling.

Bozec, A. & Zaiss, M.M.
Pflugers Arch. 2017 Apr;469(3-4):517-525. doi: 10.1007/s00424-017-1952-8. Epub 2017 Feb 28.

Latest perspectives on macrophages in bone homeostasis.

Bozec, A. & Soulat, D.
Toxins (Basel). 2017 Mar 24;9(4). pii: E115. doi: 10.3390/toxins9040115.

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors.

Backert, S. & Tegtmeyer, N.
Front Immunol. 2017 Apr 27;8:504. doi: 10.3389/fimmu.2017.00504. eCollection 2017.

Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors.

Chen J1,2, Chaurio RA2, Maueröder C2, Derer A3, Rauh M4, Kost A5, Liu Y1, Mo X6, Hueber A2, Bilyy R5, Herrmann M2, Zhao Y1, Muñoz LE2.
Semin Immunopathol. 2017 Jun;39(4):355-363. doi: 10.1007/s00281-017-0634-0. Epub 2017 Jun 8.

Cellular and molecular pathways of structural damage in rheumatoid arthritis.

Harre, U. & Schett, G
Gut Pathog. 2017; 9: 40. Published online 2017 Jul 25. doi:  10.1186/s13099-017-0189-6

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori.

Harrer, A., Boehm, M., Backert, S. & Tegtmeyer, N.
Nat Microbiol. 2016 Oct 17;2:16189. doi: 10.1038/nmicrobiol.2016.189.

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Javaheri A1,2, Kruse T3, Moonens K4,5, Mejías-Luque R1,2, Debraekeleer A4,5, Asche CI6, Tegtmeyer N6, Kalali B1,3, Bach NC7, Sieber SA7, Hill DJ8, Königer V9, Hauck CR10, Moskalenko R11, Haas R9, Busch DH1, Klaile E12,13, Slevogt H12, Schmidt A14,15, Backert S6, Remaut H4,5, Singer BB14, Gerhard M1,2,3.
Cell Death Differ. 2017 Sep;24(9):1621-1631. doi: 10.1038/cdd.2017.89. Epub 2017 Jun 2.

Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-kappa B and caspase-8-dependent apoptotic cell death.

Lim MCC1, Maubach G1, Sokolova O1, Feige MH1, Diezko R1, Buchbinder J2, Backert S3, Schlüter D4,5, Lavrik IN2, Naumann M1.
J Am Soc Nephrol. 2017 Mar;28(3):761-768. doi: 10.1681/ASN.2016040486. Epub 2016 Sep 9.

Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.

Mulay SR1, Eberhard JN1, Desai J1, Marschner JA1, Kumar SV1, Weidenbusch M1, Grigorescu M1, Lech M1, Eltrich N1, Müller L2, Hans W3, Hrabě de Angelis M3,4,5, Vielhauer V1, Hoppe B6, Asplin J7, Burzlaff N2, Herrmann M8, Evan A9, Anders HJ10.
N Engl J Med. 2017 Mar 30;376(13):1292-1294. doi: 10.1056/NEJMc1612455.

Multispectral Optoacoustic Tomography for Assessment of Crohn’s Disease Activity.

Knieling F, Neufert C, Hartmann A, Claussen J, Urich A, Egger C, Vetter M, Fischer S, Pfeifer L, Hagel A, Kielisch C, Görtz RS, Wildner D, Engel M, Röther J, Uter W, Siebler J, Atreya R, Rascher W, Strobel D, Neurath MF, Waldner MJ.
Trends Microbiol. 2017 Apr;25(4):316-328. doi: 10.1016/j.tim.2016.12.004. Epub 2017 Jan 3.

Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.

Naumann, M., Sokolova, O., Tegtmeyer, N. & Backert, S.
Front Immunol. 2017; 8: 1838. Published online 2017 Dec 22. doi:  10.3389/fimmu.2017.01838

Function of Macrophage and Parasite Phosphatases in Leishmaniasis.

Soulat, D. & Bogdan, C.
Dis Model Mech. 2017 Dec 19;10(12):1539-1540. doi: 10.1242/dmm.032813.

Helicobacter pylori infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation.

Tegtmeyer, N. & Backert, S.
Mol Microbiol. 2017 Aug;105(3):358-372. doi: 10.1111/mmi.13707. Epub 2017 May 30.

Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA.

Tegtmeyer, N., Neddermann, M., Asche, C.I. & Backert, S.
Methods Mol Biol. 2017;1559:297-309. doi: 10.1007/978-1-4939-6786-5_20

Monitoring of Chemically Induced Colitis.

Reißig S, Weigmann B.
Semin Immunopathol. 2017 Jan;39(1):89-95. doi: 10.1007/s00281-016-0603-z. Epub 2016 Nov 11.

Th9 cells in inflammatory bowel diseases.

Weigmann, B. & Neurath, M.F.
Cell Commun. Signal. 15, 5 (2017). https://doi.org/10.1186/s12964-017-0162-5

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Wessler, S., Schneider, G. & Backert, S.

2016

Front Immunol. 2016 Dec 9;7:583. doi: 10.3389/fimmu.2016.00583. eCollection 2016.

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs.

Maueröder C, Mahajan A, Paulus S, Gößwein S, Hahn J, Kienhöfer D, Biermann MH, Tripal P, Friedrich RP, Munoz LE, Neurath MF, Becker C, Schett GA, Herrmann M, Leppkes M.
Front Immunol. 2016 Dec 1;7:557. eCollection 2016.

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation.

Biermann MH, Podolska MJ, Knopf J, Reinwald C, Weidner D, Maueröder C, Hahn J, Kienhöfer D, Barras A, Boukherroub R, Szunerits S, Bilyy R, Hoffmann M, Zhao Y, Schett G, Herrmann M, Munoz LE.
Nat Med. 2016 Dec 6;22(12):1384-1386. doi: 10.1038/nm.4217.

Reply to “Neutrophils are not required for resolution of acute gouty arthritis in mice”.

Reinwald C, Schauer C, Csepregi JZ, Kienhöfer D, Weidner D, Malissen M, Mocsai A, Schett G, Herrmann M, Hoffmann M.
Nat Immunol. 2016 Nov 7. doi: 10.1038/ni.3579. [Epub ahead of print]

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.
J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17.

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.

Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S.
Front Immunol. 2016 Oct 10;7:424. eCollection 2016.

Neutrophil Extracellular Traps Form a Barrier between Necrotic and Viable Areas in Acute Abdominal Inflammation.

Bilyy R, Fedorov V, Vovk V, Leppkes M, Dumych T, Chopyak V, Schett G, Herrmann M.
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5856-E5865. Epub 2016 Sep 19.

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation.

Muñoz LE, Bilyy R, Biermann MH, Kienhöfer D, Maueröder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y, Herrmann M.

Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.
Front Immunol. 2016 Aug 12;7:302. doi: 10.3389/fimmu.2016.00302. eCollection 2016.

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.

Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M.
J Exp Med. 2016 Aug 8. pii: jem.20160316. [Epub ahead of print]

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.

von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L.
Gastroenterology. 2016 Aug;151(2):238-40. doi: 10.1053/j.gastro.2016.05.047. Epub 2016 Jun 3.

Multispectral Optoacoustic Tomography in Crohn’s Disease: Noninvasive Imaging of Disease Activity.

Waldner MJ, Knieling F, Egger C, Morscher S, Claussen J, Vetter M, Kielisch C, Fischer S, Pfeifer L, Hagel A, Goertz RS, Wildner D, Atreya R, Strobel D, Neurath MF.
J Mol Med (Berl). 2015 Jul;93(7):727-34. doi: 10.1007/s00109-015-1295-x. Epub 2015 May 24.

How neutrophil extracellular traps orchestrate the local immune response in gout.

Maueröder C, Kienhöfer D, Hahn J, Schauer C, Manger B, Schett G, Herrmann M, Hoffmann MH.
Lupus. 2016 Jul;25(8):943-54. doi: 10.1177/0961203316640919.

Reactive oxygen homeostasis – the balance for preventing autoimmunity.

Kienhöfer D, Boeltz S, Hoffmann MH.
Lupus. 2016 Jul;25(8):934-42. doi: 10.1177/0961203316640368.

Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and inflammation.

Biermann MH, Griffante G, Podolska MJ, Boeltz S, Stürmer J, Muñoz LE, Bilyy R, Herrmann M.
Biochim Biophys Acta. 2016 Jul 30. pii: S1388-1981(16)30219-0. doi: 10.1016/j.bbalip.2016.07.014. [Epub ahead of print]

The double-edged role of 12/15-lipoxygenase during inflammation and immunity.

Ackermann JA, Hofheinz K, Zaiss MM, Krönke G.
J Exp Med. 2016 Jul 25;213(8):1627-44. doi: 10.1084/jem.20160189. Epub 2016 Jul 4.

Siglec-H protects from virus-triggered severe systemic autoimmunity.

Schmitt H, Sell S, Koch J, Seefried M, Sonnewald S, Daniel C, Winkler TH, Nitschke L.
Nat Commun. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596.

Th2 and eosinophil responses suppress inflammatory arthritis.

Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G, Bozec A.
Cell Rep. 2016 May 3;15(5):1062-75. doi: 10.1016/j.celrep.2016.04.001. Epub 2016 Apr 21.

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Körner H, Bogdan C.
Oncotarget. 2016 Mar 30. doi: 10.18632/oncotarget.8474. [Epub ahead of print]

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.

Chen GL, Luo Y, Eriksson D, Meng X, Qian C, Bäuerle T, Chen XX, Schett G, Bozec A.

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Cell Death Differ. 2016 Jun;23(6):1016-25. doi: 10.1038/cdd.2016.4. Epub 2016 Mar 4.

A blast without power – cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses.

Maueröder C, Chaurio RA, Dumych T, Podolska M, Lootsik MD, Culemann S, Friedrich RP, Bilyy R, Alexiou C, Schett G, Berens C, Herrmann M, Munoz LE.
J Immunol. 2016 May 1;196(9):3581-94. doi: 10.4049/jimmunol.1502163. Epub 2016 Mar 16.

CD83 Modulates B Cell Activation and Germinal Center Responses.

Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L.
Nat Commun. 2016 Mar 11;7:10973. doi: 10.1038/ncomms10973.

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitits.

Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C.

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Ann Rheum Dis. 2016 Feb 25. pii: annrheumdis-2015-208821. doi: 10.1136/annrheumdis-2015-208821. [Epub ahead of print]

Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis.

Faustini F, Simon D, Oliveira I, Kleyer A, Haschka J, Englbrecht M, Cavalcante AR, Kraus S, Tabosa TP, Figueiredo C, Hueber AJ2, Kocijan R3, Cavallaro A5, Schett G2, Sticherling M6, Rech J2.

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Cell Death Differ. 2016 Feb 26. doi: 10.1038/cdd.2016.11. [Epub ahead of print] Review.

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.

Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M.

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Cell. 2016 Aug 11;166(4):991-1003. doi: 10.1016/j.cell.2016.06.058. Epub 2016 Jul 28.

Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages.

Stamatiades EG1, Tremblay ME2, Bohm M3, Crozet L4, Bisht K2, Kao D5, Coelho C1, Fan X6, Yewdell WT1, Davidson A7, Heeger PS8, Diebold S9, Nimmerjahn F5, Geissmann F10.

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Sci Rep. 2016 Dec 5;6:38229. doi: 10.1038/srep38229.

Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals.

Pieterse E1,2, Jeremic I2,3, Czegley C2, Weidner D2, Biermann MH2, Veissi S2, Maueröder C2, Schauer C2, Bilyy R2,4, Dumych T4, Hoffmann M2, Munoz LE2, Bengtsson AA5, Schett G2, van der Vlag J1, Herrmann M2.

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Sci Transl Med. 2016 Nov 16;8(365):365ra158. doi: 10.1126/scitranslmed.aaf9418

Elucidating the interplay between IgG-Fc valency and Fc gamma R activation for the design of immune complex inhibitors.

Ortiz DF1, Lansing JC1, Rutitzky L1, Kurtagic E1, Prod’homme T1, Choudhury A1, Washburn N1, Bhatnagar N1, Beneduce C1, Holte K1, Prenovitz R1, Child M1, Killough J1, Tyler S1, Brown J1, Nguyen S1, Schwab I2, Hains M1, Meccariello R1, Markowitz L1, Wang J1, Zouaoui R1, Simpson A1, Schultes B1, Capila I1, Ling L1, Nimmerjahn F2, Manning AM1, Bosques CJ3.

Mehr…

Semin Hematol. 2016 Apr;53 Suppl 1:S10-2. doi: 10.1053/j.seminhematol.2016.04.004. Epub 2016 Apr 6.

Immunomodulation of immunothrombocytopenia.

Nimmerjahn, F.

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J Clin Immunol. 2016 May;36 Suppl 1:83-7. doi: 10.1007/s10875-016-0249-6. Epub 2016 Mar 8.

Translating Inhibitory Fc Receptor Biology into Novel Therapeutic Approaches.

Nimmerjahn, F.

Mehr…

Nat Commun. 2016 Jan 28;7:10274. doi: 10.1038/ncomms10274.

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.

Mulay SR1, Desai J1, Kumar SV1, Eberhard JN1, Thomasova D1, Romoli S1, Grigorescu M1, Kulkarni OP1, Popper B2, Vielhauer V1, Zuchtriegel G3,4, Reichel C3,4, Bräsen JH5, Romagnani P6, Bilyy R7, Munoz LE8, Herrmann M8, Liapis H9,10, Krautwald S11, Linkermann A11, Anders HJ1.

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Mucosal Immunol. 2016 Nov;9(6):1384-1394. doi: 10.1038/mi.2016.20. Epub 2016 Mar 16.

IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells.

Mchedlidze T1, Kindermann M1, Neves AT2, Voehringer D2, Neurath MF1, Wirtz S1.

Mehr…

Int J Med Microbiol. 2016 Aug;306(5):310-315. doi: 10.1016/j.ijmm.2016.02.003. Epub 2016 Feb 17.

Faecal microbiota transplantation-A clinical view.

Mattner J1, Schmidt F2, Siegmund B3.

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Int J Mol Sci. 2016 Nov 9;17(11). pii: E1864. doi: 10.3390/ijms17111864

Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC)

Mattner, J

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Cell Rep. 2016 Feb 9;14(5):1062-73. doi: 10.1016/j.celrep.2016.01.010. Epub 2016 Jan 28.

Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis.

Martini E, Wittkopf N, Günther C, Leppkes M, Okada H, Watson AJ, Podstawa E, Backert I, Amann K, Neurath MF, Becker C.

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Cell Cycle. 2016 Nov;15(21):2875-2881. Epub 2016 Oct 7. doi: 10.1080/15384101.2016.1231286

Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF.

Martini E1, Schneider E1, Neufert C1, Neurath MF1, Becker C1.

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Semin Arthritis Rheum. 2016 Oct;46(2):143-50. doi: 10.1016/j.semarthrit.2016.05.002. Epub 2016 May 18.

High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA A combined MRI/CT study.

Kleyer A1, Krieter M1, Oliveira I1, Faustini F1, Simon D1, Kaemmerer N2, Cavalcante A3, Tabosa T3, Rech J1, Hueber A1, Schett G4.

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Sci Immunol. 2016 Dec 16;1(6). pii: eaai7677. doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Heidkamp GF1, Sander J2, Lehmann CHK1, Heger L1, Eissing N1, Baranska A1, Lühr JJ1, Hoffmann A1, Reimer KC1, Lux A3, Söder S4, Hartmann A4, Zenk J5, Ulas T2, McGovern N6, Alexiou C7, Spriewald B8, Mackensen A8, Schuler G9, Schauf B10, Forster A10, Repp R11, Fasching PA12, Purbojo A13, Cesnjevar R13, Ullrich E14,15, Ginhoux F6, Schlitzer A2,6,16, Nimmerjahn F3, Schultze JL17,16, Dudziak D18.

Mehr…

J Crohns Colitis. 2016 Jan 27. pii: jjw012. [Epub ahead of print]

High-resolution quantitative computed tomography demonstrates structural defects in cortical and trabecular bone in IBD patients.

Haschka J, Hirschmann S, Kleyer A, Englbrecht M, Faustini F, Simon D, Figueiredo CP, Schuster L, Muschitz C, Kocijan R, Resch H, Atreya R, Rech J, Neurath MF, Schett G.

Mehr…

Front Microbiol. 2016 Jan 22;6:1520. doi: 10.3389/fmicb.2015.01520. eCollection 2015.

Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response.

Fromm PD, Kling JC, Remke A, Bogdan C, Körner H.

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Gut. 2016. 2016 Jan 18. pii: gutjnl-2015-310374. doi: 10.1136/gutjnl-2015-310374. [Epub ahead of print]

IL-36R signaling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C.

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Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17.

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A.

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Cell Chem Biol. 2016 Aug 18;23(8):1014-1022. doi: 10.1016/j.chembiol.2016.07.009. Epub 2016 Aug 11.

Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections.

Broecker F, Martin CE, Wegner E, Mattner J, Baek JY, Pereira CL, Anish C, Seeberger PH.

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Methods Mol Biol. 2016;1422:253-61. doi: 10.1007/978-1-4939-3603-8_23.

Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa.

Weigmann B, Neurath MF.

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World J Gastroenterol. 2016 Nov 14;22(42):9300-9313. doi: 10.3748/wjg.v22.i42.9300

Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases.

Billmeier, U., Dieterich, W., Neurath, M.F. & Atreya, R.

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Mucosal Immunol. 2016 Sep;9(5):1205-17. doi: 10.1038/mi.2015.139. Epub 2016 Jan 27.

CD101 inhibits the expansion of colitogenic T cells.

Schey R1, Dornhoff H2, Baier JL1, Purtak M1, Opoka R3, Koller AK1, Atreya R2, Rau TT4, Daniel C5, Amann K5, Bogdan C1, Mattner J1,3.

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Int J Med Microbiol. 2016 Aug;306(5):343-355. doi: 10.1016/j.ijmm.2016.03.004. Epub 2016 Mar 15.

Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities

Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, Gläsner J, Gopalakrishnan S, Grassl GA, Günther C, Haller D, Hirose M, Ibrahim S, Loh G, Mattner J, Nagel S, Pabst O, Schmidt F, Siegmund B, Strowig T, Volynets V, Wirtz S, Zeissig S, Zeissig Y, Bleich A, Baines JF.

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Arthritis Rheumatol. 2016 Sep;68(9):2114-21. doi: 10.1002/art.39698.

Quantification and Impact of Secondary Osteoarthritis in Patients With Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis.

Figueiredo CP1, Simon D2, Englbrecht M2, Haschka J3, Kleyer A2, Bayat S2, Hueber A2, Pereira RM4, Rech J2, Schett G2.

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Blood. 2016 Jul 14;128(2):227-38. doi: 10.1182/blood-2015-11-685024. Epub 2016 Apr 20.

Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome.

Völkl S1, Rensing-Ehl A2, Allgäuer A1, Schreiner E1, Lorenz MR3, Rohr J4, Klemann C4, Fuchs I2, Schuster V5, von Bueren AO6, Naumann-Bartsch N7, Gambineri E8, Siepermann K9, Kobbe R10, Nathrath M11, Arkwright PD12, Miano M13, Stachel KD7, Metzler M7, Schwarz K14, Kremer AN1, Speckmann C15, Ehl S15, Mackensen A1.

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Mol Microbiol. 2016 Mar;99(5):925-44. doi: 10.1111/mmi.13276. Epub 2015 Dec 22.

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.

Tegtmeyer N1,2, Moodley Y3,4, Yamaoka Y5,6, Pernitzsch SR7, Schmidt V1, Traverso FR2, Schmidt TP8, Rad R9,10, Yeoh KG11, Bow H11, Torres J12, Gerhard M13, Schneider G14, Wessler S8, Backert S1,2.

Mehr…

Oncoimmunology. 2016 Aug 9;5(10):e1204506. eCollection 2016.

Macrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection.

Sektioglu IM1, Carretero R1, Bender N1, Bogdan C2, Garbi N3, Umansky V4, Umansky L5, Urban K5, von Knebel-Döberitz M6, Somasundaram V7, Wink D7, Beckhove P8, Hämmerling GJ1.

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J Immunol. 2016 Nov 15;197(10):4034-4041. Epub 2016 Oct 17.

Myeloid Cell-Derived HIF-1 alpha Promotes Control of Leishmania major.

Schatz V1, Strüssmann Y1, Mahnke A2, Schley G3, Waldner M4, Ritter U5, Wild J1, Willam C3, Dehne N6, Brüne B6, McNiff JM7, Colegio OR7, Bogdan C2, Jantsch J8.

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Cell Rep. 2016 May 24;15(8):1743-56. doi: 10.1016/j.celrep.2016.04.049. Epub 2016 May 12.

Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection.

Mahapatro M1, Foersch S1, Hefele M1, He GW1, Giner-Ventura E2, Mchedlidze T1, Kindermann M1, Vetrano S3, Danese S3, Günther C1, Neurath MF1, Wirtz S1, Becker C4.

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BMC Microbiol. 2016; 16(1): 201. Published online 2016 Sep 2. doi:  10.1186/s12866-016-0820-6

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.

Judith Lind,1 Steffen Backert,1 Rebecca Hoffmann,2 Jutta Eichler,2 Yoshio Yamaoka,3 Guillermo I. Perez-Perez,4 Javier Torres,5 Heinrich Sticht,6 and Nicole Tegtmeyercorresponding author1

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Dig Dis. 2016;34 Suppl 1:40-7. doi: 10.1159/000447281. Epub 2016 Aug 22.

Immunopathogenesis of IBD: Batf as a Key Driver of Disease Activity.

Hildner, K., Punkenburg, E., Abendroth, B. & Neurath, M.F.

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J Leukoc Biol. 2016 Jan;99(1):57-66. doi: 10.1189/jlb.5MR0515-221R. Epub 2015 Jul 31.

Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis.

Leppkes, M., Neurath, M.F., Herrmann, M. & Becker, C.

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2015

Cell Rep. 2015 Oct 20;13(3):610-20. doi: 10.1016/j.celrep.2015.09.013. Epub 2015 Oct 8.

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Schwab I, Lux A, Nimmerjahn F.

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J Cell Biol. 2015 Nov 9;211(3):553-67. doi: 10.1083/jcb.201503128

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.

Schulz AM, Stutte S, Hogl S, Luckashenak N, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA Brakebusch CH, Lichtenthaler SF, Brocker T.

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Eur J Immunol. 2015 Aug;45(8):2183-90. doi: 10.1002/eji.201445386.

A constant threat for HIV: Fc-engineering to enhance broadly neutralizing antibody activity for immunotherapy of the acquired immunodeficiency syndrome.

Nimmerjahn, F.

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Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17.

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A.

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J Clin Invest. 2015 Aug 3;125(8):3297-302. doi: 10.1172/JCI79337. Epub 2015 Jul 27.

Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma.

Koch KN, Hartung ML, Urban S, Kyburz A, Bahlmann AS, Lind J, Backert S, Taube C, Müller A.

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Cell Rep. 2015 Oct 6;13(1):70-79. doi: 10.1016/j.celrep.2015.08.074. Epub 2015 Sep 24.

H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-kappa B Target Gene Expression.

Hartung ML, Gruber DC, Koch KN, Grüter L, Rehrauer H, Tegtmeyer N, Backert S, Müller A.

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Immunol. Rev. 268, 52-65 (2015). doi: 10.1111/imr.12347

 bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression.

Gordan S, Biburger, M, Nimmerjahn F.

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Int J Mol Sci. 2015 Aug 12;16(8):18825-35. doi: 10.3390/ijms160818825.

Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment.

Fürnrohr BG, Rhodes B, Munoz LE, Weiß K, Vyse TJ, Schett G.

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