Navigation

Publications

2018

J Cell Mol Med. 2018 Sep;22(9):4399-4409. doi: 10.1111/jcmm.13735. Epub 2018 Jul 11.

The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis.

Fischer A, Abdollahi-Roodsaz S, Böhm C, Niederreiter B, Meyer B, Yau ACY, Lönnblom E, Joosten LAB, Koenders M, Lehmann CHK, Dudziak D, Krönke G, Holmdahl R, Steiner G.

Mehr

Nat Commun. 2018 Aug 15;9(1):3261. doi: 10.1038/s41467-018-05800-6

Resolution of chronic inflammatory disease: universal and tissue-specific concepts.

Schett G, Neurath MF.

Mehr

Ann Rheum Dis. 2018 Aug 17. pii: annrheumdis-2018-213223. doi: 10.1136/annrheumdis-2018-213223. [Epub ahead of print]

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation.

Pieterse E, Rother N, Yanginlar C, Gerretsen J, Boeltz S, Munoz LE, Herrmann M, Pickkers P, Hilbrands LB, van der Vlag J.
Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3.

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.

Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW.
Front. Immunol. 2018 July 31. doi.org/10.3389/fimmu.2018.01700

Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases

Rath T, Billmeier U, Ferrazzi F, Vieth M, Ekici A, Neurath MF,  Atreya R.
 
Bone. 2018 Jul 23;116:87-93. doi: 10.1016/j.bone.2018.07.017. [Epub ahead of print]

A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin.

Simon D, Kleyer A, Englbrecht M, Stemmler F, Simon C, Berlin A, Kocijan R, Haschka J, Hirschmann S, Atreya R, Neurath MF, Sticherling M, Rech J, Hueber AJ, Engelke K, Schett G.

 Dis Model Mech. 2018 Jul 25. pii: dmm.034041. doi: 10.1242/dmm.034041. [Epub ahead of print]

A model of chronic enthesitis and new bone formation characterized by multimodal imaging.

Czegley C, Gillmann C, Schauer C, Seyler L, Reinwald C, Hahn M, Uder M, Jochmann K, Naschberger E, Stock M, Schett G, Bäuerle T, Hoffmann MH.
Cell Rep. 2018 Jul 3;24(1):169-180. doi: 10.1016/j.celrep.2018.06.005.

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM.
J Bone Miner Res. 2018 Jun 27. doi: 10.1002/jbmr.3533. [Epub ahead of print]

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.

Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G.
JCI Insight. 2018 Jun 7;3(11). pii: 99712. doi: 10.1172/jci.insight.99712. [Epub ahead of print]

CD83 expression is essential for Treg cell differentiation and stability.

Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Baßler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, Wirtz S, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M.
Gut. 2018 May 30. pii: gutjnl-2017-315671. doi: 10.1136/gutjnl-2017-315671. [Epub ahead of print]

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease.

Schmitt H, Billmeier U, Dieterich W, Rath T, Sonnewald S, Reid S, Hirschmann S, Hildner K, Waldner MJ, Mudter J, Hartmann A, Grützmann R, Neufert C, Münster T, Neurath MF, Atreya R.
Front Immunol. 2018 May 25;9:1138. doi: 10.3389/fimmu.2018.01138. eCollection 2018.

Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis.

Buchele V, Abendroth B, Büttner-Herold M, Vogler T, Rothamer J, Ghimire S, Ullrich E, Holler E, Neurath MF, Hildner K.
Front Immunol. 2018 May 7;9:989. doi: 10.3389/fimmu.2018.00989. eCollection 2018.

Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus.

Biermann MHC, Boeltz S, Pieterse E, Knopf J, Rech J, Bilyy R, van der Vlag J, Tincani A, Distler JHW, Krönke G, Schett GA, Herrmann M, Muñoz LE.
Sci Transl Med. 2018 Jan 3;10(422). pii: eaag1782. doi: 10.1126/scitranslmed.aag1782.

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.

Serr I, Scherm MG, Zahm AM, Schug J, Flynn VK, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, Gerlach K, Liebsch N, Loretz B, Lehr CM, Kirchner B, Spornraft M, Haase B, Segars J, Küper C, Palmisano R, Waisman A, Willis RA, Kim WU, Weigmann B, Kaestner KH, Ziegler AG, Daniel C.
Front Immunol. 2018 Feb 5;9:79. doi: 10.3389/fimmu.2018.00079. eCollection 2018.

Type I interferon Signaling is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection.

Schleicher U, Liese J, Justies N, Mischke T, Haeberlein S, Sebald H, Kalinke U, Weiss S, Bogdan C.
Cell Syst. 2018 Jul 25;7(1):41-48.e5. doi: 10.1016/j.cels.2018.05.018. Epub 2018 Jun 27.

Dissecting Fc gamma R Regulation through a Multivalent Binding Model.

Int J Med Microbiol. 2017 Sep 14. pii: S1438-4221(17)30318-1. doi: 10.1016/j.ijmm.2017.09.010. [Epub ahead of print]

Coxiella burnetii as a useful tool to investigate bacteria-friendly host cell compartments.

Pechstein, J., Schulze-Luehrmann, J. & Luhrmann, A.
Front Immunol. 2018 Mar 16;9:535. doi: 10.3389/fimmu.2018.00535. eCollection 2018.

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.

Front Immunol. 2018 Mar 28;9:644. doi: 10.3389/fimmu.2018.00644. eCollection 2018.

A 17-kDa Fragment of Lactoferrin Associates With the Termination of Inflammation and Peptides Within Promote Resolution.

 

J Neuroimmunol. 2018 Jul 15;320:19-24. doi: 10.1016/j.jneuroim.2018.04.010. Epub 2018 Apr 16.

Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG.

 

Semin Immunopathol. 2018 Jul;40(4):379-392. doi: 10.1007/s00281-018-0677-x. Epub 2018 Mar 26.

ILC2s in infectious diseases and organ-specific fibrosis.

Kindermann, M., Knipfer, L., Atreya, I. & Wirtz, S.

 

Front Immunol. 2018 Apr 27;9:744. doi: 10.3389/fimmu.2018.00744. eCollection 2018.

CLEC10A Is a Specific Marker for Human CD1c(+) Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.

 

Mucosal Immunol. 2018 Jul;11(4):1191-1202. doi: 10.1038/s41385-018-0011-x. Epub 2018 Mar 8.

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis.

 

Matrix Biol. 2018 Aug;68-69:8-27. doi: 10.1016/j.matbio.2017.12.016. Epub 2018 Jan 31.

Targeting TGF-beta signaling for the treatment of fibrosis.

Gyorfi, A.H., Matei, A.E. & Distler, J.H.W.

 

Front Immunol. 2017; 8: 1876. Published online 2018 Jan 17. doi:  10.3389/fimmu.2017.01876

Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro.

 

J Immunol. 2018 Feb 1;200(3):983-996. doi: 10.4049/jimmunol.1701180. Epub 2017 Dec 20.

Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.

Friede, M.E., Leibelt, S., Dudziak, D. & Steinle, A.

 

Semin Arthritis Rheum. 2018 Apr;47(5):611-618. doi: 10.1016/j.semarthrit.2017.09.011. Epub 2017 Sep 23.

Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT).

 

Blood. 2018 May 17;131(20):2205-2214. doi: 10.1182/blood-2017-12-822908. Epub 2018 Mar 27.

Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia.

 

Arthritis Res Ther. 2018 May 2;20(1):84. doi: 10.1186/s13075-018-1586-z.

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.

Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL, Nimmerjahn F, Krönke G, Scherer HU, Forsblad-d’Elia H, Schett G.
Ann Rheum Dis. 2018 Jul;77(7):973-980. doi: 10.1136/annrheumdis-2017-212404. Epub 2018 Feb 23.

Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures.

Stemmler F, Simon D, Liphardt AM, Englbrecht M, Rech J, Hueber AJ, Engelke K, Schett G, Kleyer A.
Eur J Immunol. 2018 May;48(5):822-828. doi: 10.1002/eji.201747227. Epub 2018 Mar 5.

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

Haberland K, Ackermann JA, Ipseiz N, Culemann S, Pracht K, Englbrecht M, Jäck HM, Schett G, Schuh W, Krönke G.
J Clin Invest. 2018 Mar 1;128(3):916-930. doi: 10.1172/JCI89242. Epub 2018 Jan 29.

BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.

Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.
Nat Rev Rheumatol. 2018 Mar;14(3):157-169. doi: 10.1038/nrrheum.2018.10. Epub 2018 Feb 8.

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

Scherer HU, Huizinga TWJ, Krönke G, Schett G, Toes REM.
Arthritis Res Ther. 2018 Feb 7;20(1):24. doi: 10.1186/s13075-018-1527-x.

Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokineproduction in human macrophages in IDO-dependent manner.

Bozec ALuo YEngdahl CFigueiredo CBang H, Schett G.
Nat Commun. 2018 Jan 17;9(1):251. doi: 10.1038/s41467-017-02683-x.

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.

Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A.
J Immunol. 2018 Jan 12. pii: ji1700596. doi: 10.4049/jimmunol.1700596. [Epub ahead of print]

Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis.

Soare A, Weber S, Maul L, Rauber S, Gheorghiu AM, Luber M, Houssni I, Kleyer A, von Pickardt G, Gado M, Simon D, Rech J, Schett G, Distler JHW, Ramming A.
Ann Rheum Dis. 2018 Jan 8. pii: annrheumdis-2017-212489. doi: 10.1136/annrheumdis-2017-212489. [Epub ahead of print]

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.

Matei AE, Beyer C, Györfi AH, Soare A, Chen CW, Dees C, Bergmann C, Ramming A, Friebe A, Hofmann F, Distler O, Schett G, Distler JHW.
Nat Commun. 2018 Jan 4;9(1):55. doi: 10.1038/s41467-017-02490-4.

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.

Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM.
Front Microbiol. 2018 Apr 16;9:642. doi: 10.3389/fmicb.2018.00642. eCollection 2018.

Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation.

Cell Microbiol. 2018 Jun;20(6):e12845. doi: 10.1111/cmi.12845. Epub 2018 Apr 30.

Extracellular HtrA serine proteases: An emerging new strategy in bacterial pathogenesis.

Mol Microbiol. 2018 Feb;107(4):455-471. doi: 10.1111/mmi.13896. Epub 2018 Jan 18.

Type IV secretion in Gram-negative and Gram-positive bacteria.

Grohmann, E., Christie, P.J., Waksman, G. & Backert, S.
Front Immunol. 2018; 9: 1171. Published online 2018 May 30. doi:  10.3389/fimmu.2018.01171

Editorial: Immune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing.

Leppkes, M., Siegmund, B. & Becker, C.
Nano Lett. 2018 Jan 10;18(1):513-519. doi: 10.1021/acs.nanolett.7b04494. Epub 2017 Dec 19.

Visualizing Single-Cell Secretion Dynamics with Single-Protein Sensitivity.

Front Immunol. 2018 Jan 24;9:24. doi: 10.3389/fimmu.2018.00024. eCollection 2018.

Monocyte-Derived signals activate human natural Killer cells in response to Leishmania Parasites.

EMBO J. 2018 Jul 2;37(13). pii: e98665. doi: 10.15252/embj.201798665. Epub 2018 Jun 1.

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs.

Br J Dermatol. 2018 Mar;178(3):740-748. doi: 10.1111/bjd.15867. Epub 2018 Jan 22.

The genetic basis for most patients with pustular skin disease remains elusive.

Gastroenterology. 2018 Mar;154(4):778-783. doi: 10.1053/j.gastro.2018.01.009. Epub 2018 Jan 11.

Heptose 1,7-Bisphosphate Directed TIFA Oligomerization: A Novel PAMP-Recognizing Signaling Platform in the Control of Bacterial Infections.

Pachathundikandi, K. & Backert, S.
Innate Immun. 2018 Jan;24(1):11-23. doi: 10.1177/1753425917738043. Epub 2017 Nov 16.

Helicobacter pylori controls NLRP3 expression by regulating hsa-miR-223-3p and IL-10 in cultured and primary human immune cells.

Pachathundikandi, S.K. & Backert, S.
Front Immunol. 2018; 9: 1827. Published online 2018 Aug 13. doi:  10.3389/fimmu.2018.01827

Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils.

2017

Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897.

Host DNases prevent vascular occlusion by neutrophil extracellular traps.

Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA.

Mehr

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

[…] Hahn J, […] Herrmann M, […] Maueröder C, […] Mielenz D,[…], Munoz LE,[…] Vöhringer D, […] Zhao Y, […]

Mehr

Immunol Rev. 2017 Nov;280(1):26-40. doi: 10.1111/imr.12569.

Missing in action-The meaning of cell death in tissue damage and inflammation.

Muñoz LE, Leppkes M, Fuchs TA, Hoffmann M, Herrmann M.

Mehr

Nat Commun. 2017 Oct 24;8(1):1130. 8(1):1130. doi: 10.1038/s41467-017-01236-6.

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis.

Chakraborty D, Šumová B, Mallano T, Chen CW, Distler A, Bergmann C, Ludolph I, Horch RE, Gelse K, Ramming A, Distler O, Schett G, Šenolt L, Distler JHW.

Mehr

Ann Rheum Dis. 2017 Oct 25. pii: annrheumdis-2017-211501. doi: 10.1136/annrheumdis-2017-211501.

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis.

Bergmann C, Brandt A, Merlevede B, Hallenberger L, Dees C, Wohlfahrt T, Pötter S, Zhang Y, Chen CW, Mallano T, Liang R, Kagwiria R, Kreuter A, Pantelaki I, Bozec A, Abraham D, Rieker R, Ramming A, Distler O, Schett G, Distler JHW.

Mehr

Nat Rev Rheumatol. 2017 Nov 21;13(12):731-741. doi: 10.1038/nrrheum.2017.188.

Enthesitis: from pathophysiology to treatment.

Schett G, Lories RJ, D’Agostino MA, Elewaut D, Kirkham B, Soriano ER, McGonagle D.

Ann Rheum Dis. 2017 Sep 19.pii: annrheumdis-2017-211687. doi: 10.1136/annrheumdis-2017-211687.

The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study.

Schönau V, Vogel K, Englbrecht M, Wacker J, Schmidt D, Manger B, Kuwert T, Schett G.

Mehr

Cell Host Microbe. 2017 Oct 11;22(4):552-560.e5. doi: 10.1016/j.chom.2017.09.005.

Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery.

Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S.

Mehr

Front. Immunol., 28 July 2017 | https://doi.org/10.3389/fimmu.2017.00874

Neutrophil Extracellular Traps Open the Pandora’s Box in Severe Malaria

Boeltz S, Muñoz L, Fuchs T, Herrmann M.

Current Opinion in Rheumatology. 29(2):208–213, MAR 2017 DOI: 10.1097/BOR.0000000000000361

The novel interleukin-1 cytokine family members in inflammatory diseases.

Hahn M, Frey S, Hueber AJ.
Front. Immunol., 28 June 2017 | https://doi.org/10.3389/fimmu.2017.00722

Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction

Kurow O, Frey B, Schuster L, Schmitt V, Adam S, Hahn M, Gilchrist D, McInnes I, Wirtz S, Gaipl U, Krönke G, Schett G, Frey S, Hueber AJ.
Eur J Immunol. 2017 Aug 31. doi: 10.1002/eji.201646788.

Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.

Schmitt V, Hahn M, Kästele V, Wagner O, Wiendl M, Derer A, Taddeo A, Hahne S, Radbruch A, Jäck HM, Schuh W, Mielenz D, Gay S, Schett G, Hueber AJ, Frey S.
Br J Dermatol. 2017 Aug 5. doi: 10.1111/bjd.15867.

The genetic basis for most patients with pustular skin disease remains elusive.

Mössner R, Wilsmann-Theis D, Oji V, Gkogkolou P, Löhr S, Schulz P, Körber A, Christoph-Prinz J, Renner R, Schäkel K, Vogelsang L, Peters KP, Philipp S, Reich K, Ständer H, Jacobi A, Weyergraf A, Kingo K, Kõks S, Gerdes S, Steinz K, Schill T, Griewank KG, Müller M, Frey S, Ebertsch L, Uebe S, Sticherling M, Sticht H, Hüffmeier U.
Nat Med. 2017 Jul 17. doi: 10.1038/nm.4373.

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells.

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A.
J Exp Med. 2017 Jul 3;214(7):2121-2138. doi: 10.1084/jem.20161070. Epub 2017 May 31.

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O’Donnell VB, Krönke G.
J Exp Med. 2017 Jul 3;214(7):2059-2071. doi: 10.1084/jem.20160514. Epub 2017 May 31.

Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription.

Ubieta K, Garcia M, Grötsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D, Bozec A.
J Clin Invest. 2017 Jun 1;127(6):2030-2039. doi: 10.1172/JCI93356. Epub 2017 Jun 1.

Inflammatory osteolysis: a conspiracy against bone.

Mbalaviele G, Novack DV, Schett G, Teitelbaum SL.
JCI Insight. 2017 May 18;2(10). pii: 92920. doi: 10.1172/jci.insight.92920. [Epub ahead of print]

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH.
Clin Exp Immunol. 2017 May 16. doi: 10.1111/cei.12987. [Epub ahead of print]

Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during therapy.

Stümer J, Biermann MHC, Knopf J, Magorivska I, Kastbom A, Svärd A, Janko C, Bilyy R, Schett G, Sjöwall C, Herrmann M, Muñoz LE.
Arthritis Rheumatol. 2017 May 10. doi: 10.1002/art.40148. [Epub ahead of print]

Early Changes of the Cortical Micro-Channel System in the Bare Area of the Joints of Patients With Rheumatoid Arthritis.

Werner D, Simon D, Englbrecht M, Stemmler F, Simon C, Berlin A, Haschka J, Renner N, Buder T, Engelke K, Hueber AJ, Rech J, Schett G, Kleyer A.
Ann Rheum Dis. 2017 Aug;76(8):1467-1475. doi: 10.1136/annrheumdis-2016-210911. Epub 2017 May 6.

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment.

Zhang Y, Liang R, Chen CW, Mallano T, Dees C, Distler A, Reich A, Bergmann C, Ramming A, Gelse K, Mielenz D, Distler O, Schett G, Distler JHW.
J Exp Med. 2017 Jun 5;214(6):1655-1662. doi: 10.1084/jem.20160442. Epub 2017 May 5.

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.

He GW, Günther C, Thonn V, Yu YQ, Martini E, Buchen B, Neurath MF, Stürzl M, Becker C.
J Immunol. 2017 May 15;198(10):3878-3885. doi: 10.4049/jimmunol.1600638. Epub 2017 Apr 14.

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation.

Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Krönke G.
J Immunol. 2017 May 1;198(9):3436-3447. doi: 10.4049/jimmunol.1601716. Epub 2017 Mar 17.

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.

Binder N, Miller C, Yoshida M, Inoue K, Nakano S, Hu X, Ivashkiv LB, Schett G, Pernis A, Goldring SR, Ross FP, Zhao B.
J Immunol. 2017 May 1;198(9):3605-3614. doi: 10.4049/jimmunol.1601330. Epub 2017 Mar 15.

The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages.

Hannemann N, Jordan J, Paul S, Reid S, Baenkler HW, Sonnewald S, Bäuerle T, Vera J, Schett G, Bozec A.
J Exp Med. 2017 May 1;214(5):1509-1528. doi: 10.1084/jem.20160951. Epub 2017 Apr 7.

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D.
J Immunol. 2017 Mar 15;198(6):2394-2402. doi: 10.4049/jimmunol.1601472. Epub 2017 Feb 10.

Neurodegeneration Enhances the Development of Arthritis.

Lang SC, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J,Baum W, Herrmann M, Schett G, Mielenz D.
J Bone Miner Res. 2017 Apr 20. doi: 10.1002/jbmr.3158. [Epub ahead of print]

Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin.

Engdahl C, Bang H, Dietel K, Lang SC, Harre U, Schett G.
J Immunol. 2017 Mar 15;198(6):2286-2301. doi: 10.4049/jimmunol.1600802. Epub 2017 Feb 13.

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes.

Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.
Gastroenterology. 2017 Jan;152(1):176-192.e5. doi: 10.1053/j.gastro.2016.09.005. Epub 2016 Sep 14.

Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.

Popp V, Gerlach K, Mott S, Turowska A, Garn H, Atreya R, Lehr HA, Ho IC, Renz H, Weigmann B, Neurath MF.
Autoimmunity. 2017 May;50(3):151-157. doi: 10.1080/08916934.2016.1261837. Epub 2017 Jan 13.

Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites.

Sarter K, Kulagin M, Schett G, Harris NL, Zaiss MM.
Semin Arthritis Rheum. 2017 Jun;46(6):709-714. doi: 10.1016/j.semarthrit.2016.09.011. Epub 2016 Oct 3.

Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients-A longitudinal analysis.

Wunderlich, C., Oliviera, I., Figueiredo, C.P., Rech, J. & Schett, G.
Nat Protoc. 2017 Jul;12(7):1295-1309. doi: 10.1038/nprot.2017.044. Epub 2017 Jun 1.

Chemically induced mouse models of acute and chronic intestinal inflammation.

J Bone Miner Res. 2017 Apr;32(4):722-730. doi: 10.1002/jbmr.3025. Epub 2016 Nov 18.

Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis.

Nat Rev Rheumatol. 2017 Oct;13(10):621-630. doi: 10.1038/nrrheum.2017.146. Epub 2017 Sep 14.

Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

Seeling, M., Bruckner, C. & Nimmerjahn, F.
J Immunol. 2017 Jul 1;199(1):172-185. doi: 10.4049/jimmunol.1601533. Epub 2017 May 26.

 The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.

J Med Chem. 2017 Feb 9;60(3):941-956. doi: 10.1021/acs.jmedchem.6b01111. Epub 2017 Jan 19.

Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion.

Front Immunol. 2017 Oct 20;8:1318. doi: 10.3389/fimmu.2017.01318. eCollection 2017.

Editorial: NEtosis 2: the Excitement Continues.

J Immunol. 2017 May 1;198(9):3737-3745. doi: 10.4049/jimmunol.1601838. Epub 2017 Mar 27.

Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis.

Exp. Dermatol. 26, 691-696 (2017). doi: 10.1111/exd.13163

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury.

Front Immunol. 2017 Jan 27;8:16. doi: 10.3389/fimmu.2017.00016. eCollection 2017.

Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide.

Trends Immunol. 2017 Jan;38(1):29-38. doi: 10.1016/j.it.2016.10.004. Epub 2016 Oct 31.

Friend or Foe? The Ambiguous Role of Innate Lymphoid Cells in Cancer Development.

Mattner, J. & Wirtz, S.
Front Immunol. 2017 May 31;8:603. doi: 10.3389/fimmu.2017.00603. eCollection 2017.

Mechanisms of Autoantibody-Induced Pathology.

Infect Immun. 2017 Jul 19;85(8). pii: e00084-17. doi: 10.1128/IAI.00084-17. Print 2017 Aug.

Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway.

Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12.

IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.

Front Biosci (Landmark Ed). 2017 Jun 1;22:1581-1598.

The role of lipids in host microbe interactions.

Lang, R.L. & Mattner, J
Eur J Immunol. 2017 Dec;47(12):2070-2079. doi: 10.1002/eji.201747208. Epub 2017 Aug 29.

IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.

Cell Metab. 2017 Sep 5;26(3):475-492.e7. doi: 10.1016/j.cmet.2017.08.008.

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.

Kälin S1, Becker M2, Ott VB3, Serr I2, Hosp F4, Mollah MMH2, Keipert S1, Lamp D1, Rohner-Jeanrenaud F5, Flynn VK2, Scherm MG2, Nascimento LFR2, Gerlach K6, Popp V6, Dietzen S7, Bopp T7, Krishnamurthy P8, Kaplan MH8, Serrano M9, Woods SC10, Tripal P11, Palmisano R11, Jastroch M1, Blüher M12, Wolfrum C13, Weigmann B6, Ziegler AG14, Mann M4, Tschöp MH15, Daniel C16.
Gut. 2017 Apr;66(4):716-723. doi: 10.1136/gutjnl-2015-311247. Epub 2016 Aug 26.

PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.

He GW1, Günther C1, Kremer AE1, Thonn V1, Amann K2, Poremba C3, Neurath MF1, Wirtz S1, Becker C1.
Front Immunol. 2017; 8: 1922. Published online 2017 Dec 22. doi:  10.3389/fimmu.2017.01922

Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells.

Anna Hammer,1, Anne Waschbisch,1, Ilka Knippertz,2,3 Elisabeth Zinser,2,3 Johannes Berg,4 Stefanie Jörg,1 Kristina Kuhbandner,1 Christina David,4 Jingbo Pi,5 Antonios Bayas,6 De-Hyung Lee,1 Aiden Haghikia,4 Ralf Gold,4 Alexander Steinkasserer,2,3 and Ralf A. Linker1,*

 Curr Opin Microbiol. 2017 Feb;35:88-99. doi: 10.1016/j.mib.2017.03.001. Epub 2017 Mar 19.

Modulation of host cell apoptotic pathways by intracellular pathogens.

 Ann Rheum Dis. 2017 Feb;76(2):399-407. doi: 10.1136/annrheumdis-2016-209297. Epub 2016 Jun 20.

Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs

 Gastroenterology. 2017 Jul;153(1):123-138.e8. doi: 10.1053/j.gastro.2017.03.015. Epub 2017 Mar 23.

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease.

Nat Rev Rheumatol. 2017 Feb;13(2):79-86. doi: 10.1038/nrrheum.2016.200. Epub 2016 Dec 15.

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis.

Am J Pathol. 2017 May;187(5):1106-1120. doi: 10.1016/j.ajpath.2017.01.012. Epub 2017 Apr 12.

CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function.

Int Immunol. 2017 Dec 30;29(11):499-509. doi: 10.1093/intimm/dxx053.

Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation.

Brückner, C., Lehmann, C., Dudziak, D. & Nimmerjahn, F.
Curr Osteoporos Rep. 2017 Jun;15(3):121-125. doi: 10.1007/s11914-017-0356-1.

T Regulatory Cells in Bone Remodelling.

Bozec, A. & Zaiss, M.M.
Pflugers Arch. 2017 Apr;469(3-4):517-525. doi: 10.1007/s00424-017-1952-8. Epub 2017 Feb 28.

Latest perspectives on macrophages in bone homeostasis.

Bozec, A. & Soulat, D.
Toxins (Basel). 2017 Mar 24;9(4). pii: E115. doi: 10.3390/toxins9040115.

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors.

Backert, S. & Tegtmeyer, N.
Front Immunol. 2017 Apr 27;8:504. doi: 10.3389/fimmu.2017.00504. eCollection 2017.

Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors.

Semin Immunopathol. 2017 Jun;39(4):355-363. doi: 10.1007/s00281-017-0634-0. Epub 2017 Jun 8.

Cellular and molecular pathways of structural damage in rheumatoid arthritis.

Harre, U. & Schett, G
Gut Pathog. 2017; 9: 40. Published online 2017 Jul 25. doi:  10.1186/s13099-017-0189-6

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori.

Harrer, A., Boehm, M., Backert, S. & Tegtmeyer, N.
Nat Microbiol. 2016 Oct 17;2:16189. doi: 10.1038/nmicrobiol.2016.189.

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Cell Death Differ. 2017 Sep;24(9):1621-1631. doi: 10.1038/cdd.2017.89. Epub 2017 Jun 2.

Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-kappa B and caspase-8-dependent apoptotic cell death.

J Am Soc Nephrol. 2017 Mar;28(3):761-768. doi: 10.1681/ASN.2016040486. Epub 2016 Sep 9.

Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.

Trends Microbiol. 2017 Apr;25(4):316-328. doi: 10.1016/j.tim.2016.12.004. Epub 2017 Jan 3.

Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.

Naumann, M., Sokolova, O., Tegtmeyer, N. & Backert, S.
Front Immunol. 2017; 8: 1838. Published online 2017 Dec 22. doi:  10.3389/fimmu.2017.01838

Function of Macrophage and Parasite Phosphatases in Leishmaniasis.

Soulat, D. & Bogdan, C.
Dis Model Mech. 2017 Dec 19;10(12):1539-1540. doi: 10.1242/dmm.032813.

Helicobacter pylori infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation.

Tegtmeyer, N. & Backert, S.
Mol Microbiol. 2017 Aug;105(3):358-372. doi: 10.1111/mmi.13707. Epub 2017 May 30.

Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA.

Tegtmeyer, N., Neddermann, M., Asche, C.I. & Backert, S.
Semin Immunopathol. 2017 Jan;39(1):89-95. doi: 10.1007/s00281-016-0603-z. Epub 2016 Nov 11.

Th9 cells in inflammatory bowel diseases.

Weigmann, B. & Neurath, M.F.
Cell Commun. Signal. 15, 5 (2017). https://doi.org/10.1186/s12964-017-0162-5

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Wessler, S., Schneider, G. & Backert, S.

2016

Front Immunol. 2016 Dec 9;7:583. doi: 10.3389/fimmu.2016.00583. eCollection 2016.

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs.

Maueröder C, Mahajan A, Paulus S, Gößwein S, Hahn J, Kienhöfer D, Biermann MH, Tripal P, Friedrich RP, Munoz LE, Neurath MF, Becker C, Schett GA, Herrmann M, Leppkes M.
Front Immunol. 2016 Dec 1;7:557. eCollection 2016.

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation.

Biermann MH, Podolska MJ, Knopf J, Reinwald C, Weidner D, Maueröder C, Hahn J, Kienhöfer D, Barras A, Boukherroub R, Szunerits S, Bilyy R, Hoffmann M, Zhao Y, Schett G, Herrmann M, Munoz LE.
Nat Med. 2016 Dec 6;22(12):1384-1386. doi: 10.1038/nm.4217.

Reply to “Neutrophils are not required for resolution of acute gouty arthritis in mice”.

Reinwald C, Schauer C, Csepregi JZ, Kienhöfer D, Weidner D, Malissen M, Mocsai A, Schett G, Herrmann M, Hoffmann M.
Nat Immunol. 2016 Nov 7. doi: 10.1038/ni.3579. [Epub ahead of print]

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.
J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17.

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.

Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S.
Front Immunol. 2016 Oct 10;7:424. eCollection 2016.

Neutrophil Extracellular Traps Form a Barrier between Necrotic and Viable Areas in Acute Abdominal Inflammation.

Bilyy R, Fedorov V, Vovk V, Leppkes M, Dumych T, Chopyak V, Schett G, Herrmann M.
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5856-E5865. Epub 2016 Sep 19.

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation.

Muñoz LE, Bilyy R, Biermann MH, Kienhöfer D, Maueröder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y, Herrmann M.

Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.
Front Immunol. 2016 Aug 12;7:302. doi: 10.3389/fimmu.2016.00302. eCollection 2016.

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.

Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M.
J Exp Med. 2016 Aug 8. pii: jem.20160316. [Epub ahead of print]

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.

von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L.
Gastroenterology. 2016 Aug;151(2):238-40. doi: 10.1053/j.gastro.2016.05.047. Epub 2016 Jun 3.

Multispectral Optoacoustic Tomography in Crohn’s Disease: Noninvasive Imaging of Disease Activity.

Waldner MJ, Knieling F, Egger C, Morscher S, Claussen J, Vetter M, Kielisch C, Fischer S, Pfeifer L, Hagel A, Goertz RS, Wildner D, Atreya R, Strobel D, Neurath MF.
J Mol Med (Berl). 2015 Jul;93(7):727-34. doi: 10.1007/s00109-015-1295-x. Epub 2015 May 24.

How neutrophil extracellular traps orchestrate the local immune response in gout.

Maueröder C, Kienhöfer D, Hahn J, Schauer C, Manger B, Schett G, Herrmann M, Hoffmann MH.
Lupus. 2016 Jul;25(8):943-54. doi: 10.1177/0961203316640919.

Reactive oxygen homeostasis – the balance for preventing autoimmunity.

Kienhöfer D, Boeltz S, Hoffmann MH.
Lupus. 2016 Jul;25(8):934-42. doi: 10.1177/0961203316640368.

Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and inflammation.

Biermann MH, Griffante G, Podolska MJ, Boeltz S, Stürmer J, Muñoz LE, Bilyy R, Herrmann M.
Biochim Biophys Acta. 2016 Jul 30. pii: S1388-1981(16)30219-0. doi: 10.1016/j.bbalip.2016.07.014. [Epub ahead of print]

The double-edged role of 12/15-lipoxygenase during inflammation and immunity.

Ackermann JA, Hofheinz K, Zaiss MM, Krönke G.
J Exp Med. 2016 Jul 25;213(8):1627-44. doi: 10.1084/jem.20160189. Epub 2016 Jul 4.

Siglec-H protects from virus-triggered severe systemic autoimmunity.

Schmitt H, Sell S, Koch J, Seefried M, Sonnewald S, Daniel C, Winkler TH, Nitschke L.
Nat Commun. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596.

Th2 and eosinophil responses suppress inflammatory arthritis.

Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G, Bozec A.
Cell Rep. 2016 May 3;15(5):1062-75. doi: 10.1016/j.celrep.2016.04.001. Epub 2016 Apr 21.

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Körner H, Bogdan C.
Oncotarget. 2016 Mar 30. doi: 10.18632/oncotarget.8474. [Epub ahead of print]

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.

Chen GL, Luo Y, Eriksson D, Meng X, Qian C, Bäuerle T, Chen XX, Schett G, Bozec A.

Mehr…

Cell Death Differ. 2016 Jun;23(6):1016-25. doi: 10.1038/cdd.2016.4. Epub 2016 Mar 4.

A blast without power – cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses.

Maueröder C, Chaurio RA, Dumych T, Podolska M, Lootsik MD, Culemann S, Friedrich RP, Bilyy R, Alexiou C, Schett G, Berens C, Herrmann M, Munoz LE.

J Immunol. 2016 May 1;196(9):3581-94. doi: 10.4049/jimmunol.1502163. Epub 2016 Mar 16.

CD83 Modulates B Cell Activation and Germinal Center Responses.

Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L.
Nat Commun. 2016 Mar 11;7:10973. doi: 10.1038/ncomms10973.

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitits.

Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C.

Mehr…

Ann Rheum Dis. 2016 Feb 25. pii: annrheumdis-2015-208821. doi: 10.1136/annrheumdis-2015-208821. [Epub ahead of print]

Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis.

Faustini F, Simon D, Oliveira I, Kleyer A, Haschka J, Englbrecht M, Cavalcante AR, Kraus S, Tabosa TP, Figueiredo C, Hueber AJ2, Kocijan R3, Cavallaro A5, Schett G2, Sticherling M6, Rech J2.

Mehr…

Cell Death Differ. 2016 Feb 26. doi: 10.1038/cdd.2016.11. [Epub ahead of print] Review.

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.

Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M.

Mehr…

Cell. 2016 Aug 11;166(4):991-1003. doi: 10.1016/j.cell.2016.06.058. Epub 2016 Jul 28.

Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages.

Sci Rep. 2016 Dec 5;6:38229. doi: 10.1038/srep38229.

Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals.

Sci Transl Med. 2016 Nov 16;8(365):365ra158. doi: 10.1126/scitranslmed.aaf9418

Elucidating the interplay between IgG-Fc valency and Fc gamma R activation for the design of immune complex inhibitors.

Semin Hematol. 2016 Apr;53 Suppl 1:S10-2. doi: 10.1053/j.seminhematol.2016.04.004. Epub 2016 Apr 6.

Immunomodulation of immunothrombocytopenia.

Nimmerjahn, F.

Mehr…

J Clin Immunol. 2016 May;36 Suppl 1:83-7. doi: 10.1007/s10875-016-0249-6. Epub 2016 Mar 8.

Translating Inhibitory Fc Receptor Biology into Novel Therapeutic Approaches.

Nimmerjahn, F.

Mehr…

Nat Commun. 2016 Jan 28;7:10274. doi: 10.1038/ncomms10274.

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.

Mucosal Immunol. 2016 Nov;9(6):1384-1394. doi: 10.1038/mi.2016.20. Epub 2016 Mar 16.

IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells.

Int J Med Microbiol. 2016 Aug;306(5):310-315. doi: 10.1016/j.ijmm.2016.02.003. Epub 2016 Feb 17.

Faecal microbiota transplantation-A clinical view.

Mattner J1, Schmidt F2, Siegmund B3.

Mehr…

Int J Mol Sci. 2016 Nov 9;17(11). pii: E1864. doi: 10.3390/ijms17111864

Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC)

Mattner, J

Mehr…

Cell Rep. 2016 Feb 9;14(5):1062-73. doi: 10.1016/j.celrep.2016.01.010. Epub 2016 Jan 28.

Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis.

Martini E, Wittkopf N, Günther C, Leppkes M, Okada H, Watson AJ, Podstawa E, Backert I, Amann K, Neurath MF, Becker C.

Mehr…

Cell Cycle. 2016 Nov;15(21):2875-2881. Epub 2016 Oct 7. doi: 10.1080/15384101.2016.1231286

Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF.

Martini E1, Schneider E1, Neufert C1, Neurath MF1, Becker C1.

Mehr…

Semin Arthritis Rheum. 2016 Oct;46(2):143-50. doi: 10.1016/j.semarthrit.2016.05.002. Epub 2016 May 18.

High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA A combined MRI/CT study.

Kleyer A1, Krieter M1, Oliveira I1, Faustini F1, Simon D1, Kaemmerer N2, Cavalcante A3, Tabosa T3, Rech J1, Hueber A1, Schett G4.

Mehr…

Sci Immunol. 2016 Dec 16;1(6). pii: eaai7677. doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Heidkamp GF1, Sander J2, Lehmann CHK1, Heger L1, Eissing N1, Baranska A1, Lühr JJ1, Hoffmann A1, Reimer KC1, Lux A3, Söder S4, Hartmann A4, Zenk J5, Ulas T2, McGovern N6, Alexiou C7, Spriewald B8, Mackensen A8, Schuler G9, Schauf B10, Forster A10, Repp R11, Fasching PA12, Purbojo A13, Cesnjevar R13, Ullrich E14,15, Ginhoux F6, Schlitzer A2,6,16, Nimmerjahn F3, Schultze JL17,16, Dudziak D18.

Mehr…

J Crohns Colitis. 2016 Jan 27. pii: jjw012. [Epub ahead of print]

High-resolution quantitative computed tomography demonstrates structural defects in cortical and trabecular bone in IBD patients.

Haschka J, Hirschmann S, Kleyer A, Englbrecht M, Faustini F, Simon D, Figueiredo CP, Schuster L, Muschitz C, Kocijan R, Resch H, Atreya R, Rech J, Neurath MF, Schett G.

Mehr…

Front Microbiol. 2016 Jan 22;6:1520. doi: 10.3389/fmicb.2015.01520. eCollection 2015.

Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response.

Fromm PD, Kling JC, Remke A, Bogdan C, Körner H.

Mehr…

Gut. 2016. 2016 Jan 18. pii: gutjnl-2015-310374. doi: 10.1136/gutjnl-2015-310374. [Epub ahead of print]

IL-36R signaling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C.

Mehr…

Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17.

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A.

Mehr…

Cell Chem Biol. 2016 Aug 18;23(8):1014-1022. doi: 10.1016/j.chembiol.2016.07.009. Epub 2016 Aug 11.

Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections.

World J Gastroenterol. 2016 Nov 14;22(42):9300-9313. doi: 10.3748/wjg.v22.i42.9300

Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases.

Billmeier, U., Dieterich, W., Neurath, M.F. & Atreya, R.

Mehr…

Arthritis Rheumatol. 2016 Sep;68(9):2114-21. doi: 10.1002/art.39698.

Quantification and Impact of Secondary Osteoarthritis in Patients With Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis.

Blood. 2016 Jul 14;128(2):227-38. doi: 10.1182/blood-2015-11-685024. Epub 2016 Apr 20.

Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome.

Mol Microbiol. 2016 Mar;99(5):925-44. doi: 10.1111/mmi.13276. Epub 2015 Dec 22.

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.

Oncoimmunology. 2016 Aug 9;5(10):e1204506. eCollection 2016.

Macrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection.

J Immunol. 2016 Nov 15;197(10):4034-4041. Epub 2016 Oct 17.

Myeloid Cell-Derived HIF-1 alpha Promotes Control of Leishmania major.

Cell Rep. 2016 May 24;15(8):1743-56. doi: 10.1016/j.celrep.2016.04.049. Epub 2016 May 12.

Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection.

BMC Microbiol. 2016; 16(1): 201. Published online 2016 Sep 2. doi:  10.1186/s12866-016-0820-6

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.

Dig Dis. 2016;34 Suppl 1:40-7. doi: 10.1159/000447281. Epub 2016 Aug 22.

Immunopathogenesis of IBD: Batf as a Key Driver of Disease Activity.

Hildner, K., Punkenburg, E., Abendroth, B. & Neurath, M.F.

Mehr…

J Leukoc Biol. 2016 Jan;99(1):57-66. doi: 10.1189/jlb.5MR0515-221R. Epub 2015 Jul 31.

Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis.

Leppkes, M., Neurath, M.F., Herrmann, M. & Becker, C.

Mehr…

2015

Cell Rep. 2015 Oct 20;13(3):610-20. doi: 10.1016/j.celrep.2015.09.013. Epub 2015 Oct 8.

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Schwab I, Lux A, Nimmerjahn F.

Mehr…

J Cell Biol. 2015 Nov 9;211(3):553-67. doi: 10.1083/jcb.201503128

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.

Schulz AM, Stutte S, Hogl S, Luckashenak N, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA Brakebusch CH, Lichtenthaler SF, Brocker T.

Mehr…

Eur J Immunol. 2015 Aug;45(8):2183-90. doi: 10.1002/eji.201445386.

A constant threat for HIV: Fc-engineering to enhance broadly neutralizing antibody activity for immunotherapy of the acquired immunodeficiency syndrome.

Nimmerjahn, F.

Mehr…

Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17.

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

J Clin Invest. 2015 Aug 3;125(8):3297-302. doi: 10.1172/JCI79337. Epub 2015 Jul 27.

Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma.

Cell Rep. 2015 Oct 6;13(1):70-79. doi: 10.1016/j.celrep.2015.08.074. Epub 2015 Sep 24.

H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-kappa B Target Gene Expression.

Immunol. Rev. 268, 52-65 (2015). doi: 10.1111/imr.12347

 bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression.

Gordan, S., Biburger, M. & Nimmerjahn, F.

Mehr…

Int J Mol Sci. 2015 Aug 12;16(8):18825-35. doi: 10.3390/ijms160818825.

Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment.

Fürnrohr BG, Rhodes B, Munoz LE, Weiß K, Vyse TJ, Schett G.

Mehr…

Addition informations